胆色素的代谢与黄疸(国外英文资料).docVIP

胆色素的代谢与黄疸 Clinical   class 2 Zheng Zheng iron porphyrin compound  hemoglobin, myoglobin, etc  bile pigment (bilirubin) bilirubin (bile pigment) biliverdin bile pigment, biliverdin) original (bilinogen) Bile pigment (bilin)  bile pigment the original clan compounds colorless   the rest all have certain color is generally referred to as the bile pigment, the concept of bile pigment bilirubin bile pigment is a kind of  its bravery The main pigments in the juice  in orange. It is the body of iron porphyrin compound   main metabolites have toxicity to cause irreversible damage to the brain and nervous system  but there are also antioxidant power Can  can inhibit the oxidation of linoleic acid and phospholipid. Bilirubin is a clinically important basis for determining jaundice  is also an important index of liver function. Bilirubin is the degradation product of iron porphyrins  body iron porphyrins including   hemoglobin myoglobin  cytochrome  catalase and peroxidase  a normal person can generate 250-350 mg a day of bilirubin  more than 80% of which comes from the aging of red blood cell hemoglobin released by destruction of red blood cells in the process of decomposition  small part from hematopoietic premature failure or invalid, the major source of the generation of red blood cell hemoglobin  heme is formed by four pyrrole ring joint  ring compounds and chelating a bivalent iron ion.  so far found that heme hydrogenation of exist three enzymes in the body mainly exist in the liver, spleen and bone marrow on aging red blood cells, tissues and organs.  hemoglobin after catalytic formation is the main purpose of biliverdin  biliverdin again after further catalyst The posterior reduction produces bilirubin. Bilirubin transformation  bilirubin in liver cells in liver converted into combination of bilirubin and secrete into the bile duct  of bilirubin in the blood bilirubin, albumin complexes in the form of transportation to the liver after  i