严重呼吸困难患者血浆脑钠肽水平及意义.pdfVIP

中国急救医学2仅)6年 11 月第26 卷第 II 期( Ghin J Grit Care Med. Nov. 2创始，VoI26 ， NιII) • 817 • ·论著· 严重呼吸困难患者血浆脑纳肤水平及意义 张春红， 罗北捷， 黄党生， 沈 东， 张许文， 王秋霜， 张丽伟， 白 静 [摘 要] 目的探讨严重呼吸困难患者血浆脑纳J1t(8NP) 水平及其与心功能的关系，为 8NP 在呼吸困难鉴别诊断中 9 提供理论依据。方法 使用 8IOSITE 公司的 Triage 8NP 千氏快速诊断方法对65 例心源性呼吸困难、40 例肺源性呼吸困难患 者的 8NP 进行测量，比较其浓度间的差异，并比较心源性呼吸困难患者 8NP 与心功能的关系。结果 心力衰竭组与正常对 照组及肺源性呼吸困难组的 8NP 水平差异有统计学意义( P 0. ∞1 )。在严重心源性呼吸困难纽未观察到呼吸困难时 8NP 与 LVEDD 及EF 的相关性。结论 血浆 BNP 水平测定是严重呼吸困难患者一敏感而特异的鉴别诊断标志物。 [关键词] 脑纳肤; 呼吸困难; 心力衰竭 [中图分类号] R54 1. 6 [文献标识码] A [文章编号] 1∞2 -1949(2创淄川1 -0817 -02 Sigr曲canωof brain natriuretic peptide in the patients with severe dyspn倒 ZHANG Chun - ho晤， LUO Beì-jí白， HUANGDang - sheng ,et al. Beijìng Fìrst f\庐lìωed Hospìtal (扩PLA General Hospìtal , Beijìng 1αXl37 ， Chìna [Abstract] 0崎ective To evaluate the serum level of 8NP in the patients with severe dyspnea and to discuss the relationship with heart function in order to provide the evidence for the diagnosis of dyspnea. Method 8100d samples of 65 heart failure patients , 38 pulmonic dyspnea patients ,20 healthy individuals were collected. 8 - type natriuretic peptide wωmeasured with a bedside assay ( Triage 8NP test) . Result There were statistical significances in the 8NP level between heart failure group and two other groups ( P O. ∞1 ) ,and the level of BNP wωsignificantly higher in the patients with pulmonary disease than in the controls. 币lere wωno relation- ship between the level of 8NP and left ventricular end - diastolic diameter( LVEDD) and ejection fraction( EF ) in the patients with se- vere cardiac dyspnea. Conclusion 8NP is a sensitive and specific indicator for the diagnosis of severe dyspnea. [Key words] 8rain natriuretic p今tide j Dyspnea j Heart failure 脑锅肤(hrai