严重四肢骨折患者血浆中D-二聚体的变化及其临床意义.pdfVIP

608 • THE JOURNAL OF OONE AND )0111 1 INJURY VoI.l9.NO.9回归p.2004 ·论 著· 严重四肢骨折患者血浆中 D一二聚体的 变化及其临床意义 郝振海‘ j司东生· 张进旅‘ 摘要 目的 探讨严重囚胶骨折并消化道出血的发病因素。 方法 对 71 例严重四肢骨折患者采用乳胶凝集法(半定量法)测 定血浆中 0- 二聚休。 结果 严震四肢骨折患者伤后 1 、 3 d , 1 、 2 周血浆中 D- 二wt体浓度均比正常对照组里不同程度的增 高 (PO.OI) ; 同时显示:严重四肢骨折患者合并消化道出血组与不合并消化道出血组血浆中 D- 二聚体含黛存在显著位差 异 (P0. 05)。 结论 严Æ四月宜骨折并消化道出血的发病因素与串连血机制异常有关。 关键词 严:m四肢骨折; 消化道出血; D- 二聚体 Chang四 and Clinical Slgnificance of D - dimer in 11捕m of the Patients with Severe Fractures ot Upper and Lower Llmbs Hao Zhenhai , Zhou Dongslleng , Zhang Jínlu. Department 0/ Traumatic Ortlloμ， edi口， Shandong Pro四ncial Hos如tal ， Jinan , 250021 Abst ract Objectlve To study pathog四ic element on gastroint臼tinal bleeding fo llowing severe fractur醋。f upp町 and lower limbs. Melhods 0 - dimer in plasm of seventy - one patients adnùtt创 betw回n January 2002 and February 2003 with 民vere fractures of upper and lower limbs wer e determined by lacteprene ∞agulation method (haif - quantilication). R白0115 Plasma 0 - dimer levels in all 辑ven­ ty - one pati ents with 出vere fractures of upper and lower limbs were sign.iIicandy higher at 1日， 3时， 7th， 14th day of postinjury than tbooe 01 the normal control group (P 0 .0 1 ). There w田c significantly differcnce betwccn the patien臼 with ga就romt由tinal bleeding 10Uowing 盹V盯e Iractur咽。f upper and lower lirnbs and the patients with non - gastroint臼tinal blecding following 提vere fractur目. 。1 upper and lower limbs (P 0 .05) . Conclus ion T he pathogenic element 01 g础troint臼ti nal bleeding lollowing severe fractur白。1 upper and lower Limbs is related ìo blood coagulation disfunction. Key words Severe fractures of upper and lower limbs; Gastrointestinal bleeding; D - dimer 骨扬并尺4盖骨骨折 7 例。开放性骨折29 例，闭合性