阴沟肠杆菌感染的临床分布及耐药性变迁.pdfVIP

生物技术通讯 711 LËTTERS INÏnOTECHNOLOCÿ Vo l.25 No.5 Sep. , 2014 doi: 1O.3969/j.i ssn.l∞9-αJ02.20 14.05.025 技术方法 阴沟肠杆菌感染的临床分布及耐药性变迁 杨至宜，胡塔 广州军区广州总医院检验科，广东广州 51∞10 [摘要] 目的:分析阴沟肠杆菌感染的临床分布及耐药性变迁，为临床合理用药提供指导。方法:采用临床微生物指 南中的常规方法对医院各类标本进行分离培养，对医院近3 年阴沟肠杆菌感染的临床分布及耐药性变迁情况进行总 结分析。结果:2∞9 年 12 月 -2011 年 12 月，从临床标本中共分离出 165 株阴沟肠杆菌，菌株的主要来源为痰液、尿液 和其他分泌物，分别占 50.39毛、32.7%和 279毛;临床药物敏感试验结果显示，阴沟肠杆菌对头抱菌素类、青霉素类、氯霉 素和氨基糖苦类的抗菌药物呈现较高的耐药率，对亚胶培南、头子包比肪比较敏感，而头子包西丁、氨韦西林及头子包哇林 对阴沟肠杆菌无效。结论:阴沟肠杆菌主要导致呼吸道和尿路感染，是一种对多种抗菌素耐药的高耐药性细菌，临床 医生应结合临床药敏结果合理地选用抗菌药物，以减少耐药菌株的产生和蔓延。 [关键词] 阴沟肠杆菌;耐药性;抗菌药物;ß- 内曹先胶酶;AmpC 酶 [申图分类号] R446 [文献标识码] A [文章编号] 1 ∞9-∞02(2014)05-0711-03 Analysis of Clinical Distribution and Drug Resistance of Infection due to Enterobacter cloacae YANG Zhi-Y;户， HU Ta Clinical Laboratory of General Hospital of Guangzhou Military Command. Guangzhou 51∞10， China *Corresponding author, E-mail: gemey888@126.com [Abstract] Objective: To investigate the clinical distribution and antimicrobial resistance of infections caused by Enterobacter cloacae in our hospital for guiding the clinical application of antibiotics reasonably. Methods: Retro- spective analysis of the drug resistance situation and specimen distribution were made to the E.cloacae isolated from our hospital in the recent 3 years. Results: Totally 165 strains of E.cloacae were isolated between Dec. , 2009 and Dec吁 2011 ， the percentages of these strains isolated from sputum, urine and the others were 50.3% , 32.7% and 279毛 respectively. Conclusion: E.cloacae mainly causes infections of respiratory tract and urinary tract in clinic. E.cloαcae is multidrug resistant and severely resistant to the third generation cepholosporins. It is suggest- ed that antibio