慢性阻塞性肺疾病骨骼肌萎缩的治疗现状.PDFVIP

临床与病理杂志 2017, 37(4) J Clin Path ol R e s 831 doi: 10.3978/j.issn.2095-6959.2017.04.031 View this article at: /10.3978/j.issn.2095-6959.2017.04.031 慢性阻塞性肺疾病骨骼肌萎缩的治疗现状 1 2 黄惠芝 综述 胡瑞成 审校 (1. 南华大学附属省马王堆医院呼吸内科，长沙 410016；2. 湖南省人民医院呼吸内科，长沙 410016) [摘　要] 慢性阻塞性肺疾病 (chronic obstructive pulmonary disease ，COPD)不仅是一种局限于呼吸道和肺部 的疾病，还是一种可以累及肺外各器官的全身疾病，其肺外效应包括心血管疾病、焦虑和抑郁及 骨骼肌萎缩等疾病，其中骨骼肌萎缩严重影响患者的生活质量及预后，造成巨大的社会和经济负 担。然而，肌肉组织固有的适应性为骨骼肌萎缩提供了治疗机会。适当的干预措施可逆转或延迟 骨骼肌萎缩的发展进程。 [关键词] 慢性阻塞性肺疾病；骨骼肌萎缩；治疗 Actuality of treatment of muscle atrophy in chronic obstructive pulmonary disease 1 2 HUANG Huizhi , HU Ruicheng (1. Department of Respiratory, Hunan Mawangdui Hospital Affiliated to University of South China, Changsha 410016; 2. Department of Respiratory, Hunan Provincial People’s Hospital, Changsha 410016, China) Abstract Chronic obstructive pulmonary disease (COPD) is not only a disease limited to the airway and lung, but also a systemic disease involving extrapulmonary organs, the extrapulmonary effects including cardiovascular disease, anxiety and depression, skeletal muscle atrophy. Skeletal muscle atrophy seriously impact patients’ life quality and prognosis, which cause huge social and economic burden. However, the inherent adaptability of muscle tissue offers therapeutic opportunities to tackle muscle atrophy. Appropriate interventions can reverse or delay the development