NF-κB(p65)蛋白核转位与唾液腺腺样囊性癌侵袭和转移关系的研究.pdfVIP

.189. 韭Æ口眩目层学 2010 年第 18 卷第4 期 时且坚业凹兰亚笠凹剌盟问且皿到盟盟ι凹L且本卫生主 NF.寸B( p65) 蛋白核转位与唾液腺腺样囊性癌 侵袭和转移关系的研究 严明张萍王丽珍张春叶吕战陈万涛 {摘要} 目的 检测 NF-KB p65 蛋白在曦液腺腺样囊性癌(adenoid cystic carcinoma , ACC) 临床组织标本中的 表达水平和转位情况，分析其与 ACC 侵袭和转移之间的关系。方法 应用免疫组织化学法，检测 58 例唾液腺腺 样囊性癌石蜡标本中p65 蛋白的表达和细胞定位，分析p65 蛋白的表达、转位与 ACC 转移和其他临床病理参数的 关系。结果 在转移和非转移的 ACC 组，p65 细胞表达阳性率先扭着差异( p = O. 2641 ) ;而p65 蛋白的核阳性表 达率ACC 转移组明显高于非转移组(P =0. 026 1) ，并且与 ACC 神组提润相关(P=O.0244) 。结论 NF-KB 通路的 撒洒可能在E浓浓腺腺样囊性精侵袭和转移中发挥竟要作用。 [央键词] NF-KB p65 蛋白: 唾液腺腺样囊1咳癌; 转移 {中圄号] R780.23 [文献标识码1 A [文章编号] lC附16-673X(却10)04-0 189-04 Transl时翩。n of NF-ICB 1165 may be correlated with the invasion 棚d metasωsis of salivary adenoid cys创c carcinoma YAN Ming ,ZHANG Ping , WANG μ唰zhen ， ZHANG Chun啊， LV Yan , CHEN Wan-tω. Departl1umt Qf Oral αnd Maxillofiαcial Surgery , Shanghai Ninth People s Hospital , ~胁时 of Medicine , Shanghai Jiaoωng Univers町. s.阳nghω 2α，)()ll ， China [ Abstract] Objective To examine the 悦pression level 川F-KB p65 protein and its translocation in the 阳阳of salivary adenoíd cystic carcinoma and to analyze theír relationship to the invasion and metastasís of ACC. Meth叫s The p65 protein expression was eXlilllÍ noo in 58 patients wi伽 adenoíd cystíc carcinom幽 of salivary 再land by immunohistochemical stainin移刊e relationship between p65 protein and ACC metastasís and invasion was analyzed.四e 翩翩i阳n between p65 expression levels and the c1inicopathological I阳翩翩阳附陀巾o examíned. Results There was 00 sí伊血cant difference of p65 阴暗itive rate between the non-metastatic group and the metastatic group. But the p65 nudear 阳itive rate wωhigher in the metastatic group th刷 in the n棚-metastatic group ，制d the p65 nuclear expression level was re