丹皮酚希夫碱及其铜配合物的合成与抗菌活性-学兔兔 www.xuetutu.com.pdfVIP

学兔兔 2015年第23卷 合 成化学 Vo1．23，2015 第8期，733～735 Chinese Joumal of Synthetic Chemistry No．8，733—735 · 快递论文· 丹皮酚希夫碱及其铜配合物的合成与抗菌活性 刘存芳，王 芹，王 奇，豆佳媛，赖普辉 (陕西理工学院化学与环境科学学院，陕西汉中 723000) 摘要：采用水蒸汽蒸馏法从牡丹皮中提取并精制得丹皮酚(1)；1与硫代氨基脲经缩合反应制得新化合物丹皮 酚希夫碱(2)，收率61％；2与二水氯化铜反应合成了丹皮酚希夫碱铜配合物(3)，收率53％，其结构经 UV—Vis， H NMR，”C NMR，IR和元素分析表征。抗菌活性测试结果表明，2和3对大肠埃希氏菌、金黄色葡 萄球菌、绿脓假单胞菌及白假丝酵母菌均有较强的抑菌和杀菌作用，尤其是3对金黄色葡萄球菌的抑制和灭活 作用较显著，MIC和MBC分别为2．2O g·mL 和8．60 g·mL～。 关 键 词：丹皮酚；希夫碱；铜配合物；合成；抗菌活性 中图分类号：0625；0627 文献标识码：A DOI：10．15952／j．cnki．cjsc．1005—1511．2015．08．0733 Synthesis and Antimicrobial Activities of a Novel Paeonol Derivative and Its Copper Complex LIU Cun—fang，WANG Qin，WANG Qi，DOU Jia—yuan，LAI Pu-hui (School of Chemistry and Environment Science，Shanxi University of Technology，Hanzhong 723000，China) Abstract：Paeonol(1)was extracted by steam distillation from paenoia surf ruicosa．A novel paeonol Schiff base(2)with the yield of61％was synthesized by condensation reaction of 1 with sulfur gener- ation semicarbazide．The copper complex(3)with the yield of 53％was synthesized by reaction of 2 with CuC12·2H2 O．The structures were characterized by UV．Vis， H NMR， C NMR，IR and ele— mental analysis．The antimicrobial activities of 2 and 3 were investigated．The results showed that 2 and 3 exhibited good bacteriostasic activities and bactericidal activities against Escherichia coli， Staphylococcus aureus，Pesudomonas pyocyaneum and Canidia albicans，especially，MIC and MBC of 3 against Staphylococcus aureus were 2．20 Ixg·mL～and 8．60 g·mL～，respectively． Keywords：paeonol；Schiff base；copper complex；synth