长庚大学学生出席国际会议报告书.PDFVIP

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长庚大学学生出席国际会议报告书

99 06 30 
 
 D9601305 990606 ~ 990611 99 5 28 
 
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 () Keystone symposia - Bioactive Lipids: Biochemistry and Diseases ( )
 







 () () Mitochondrial Ca2+- and ROS-independent depletion of cardiolipin by arachidonic acid and its protection by NO in RBA-1 astrocyte Astrocytes, in addition to support neuron network in the central nerve system (CNS), are actively involved in synaptic transmission and neurovascular coupling for neuron survival. Cardiolipin (CL), a richest phospholipid located exclusively in the mitochondrial inner membrane, is crucial for maintaining mitochondrial membrane stability including individual complex of mitochondrial respiratory chain (RC) involved in energy production, mitochondrial Ca2+ (mCa2+) regulation and reactive oxygen spices (ROS) formation. We observed that AA dose-dependently induced apoptosis of RBA1 astrocytes. In addition to significant elevation of cytosolic Ca2+ (cCa2+) that followed by increase in mCa2+ and mitochondrial ROS (mROS) and depolarization of ∆Ψm, AA-induced apoptosis involved fast depletion of CL and fission of mitochondria. Interestingly, AA-induced depletion of CL and fission preceded increase o

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