结直肠癌化疗(国外英文资料).docVIP

结直肠癌化疗(国外英文资料) Colorectal cancer With the improvement of living standards, the incidence of colorectal cancer in our country is growing at an annual rate of 4.2 percent, which is a serious threat to the lives and health of people. The commonly accepted treatment of colorectal cancer is the comprehensive treatment of first-choice surgery. Adjuvant chemotherapy is an important part of comprehensive treatment and is also the main method for preventing distant metastasis. However, the therapeutic role of chemotherapy in colorectal cancer has long been suspected. In recent years, with the development of modern pharmacology and modern molecular biology, the role of adjuvant chemotherapy in colorectal cancer is gradually improving. At present, colorectal cancer adjuvant chemotherapy has become one of the most active areas of clinical investigation of cancer. The history of complementary chemotherapy for colorectal cancer Colorectal cancer adjuvant chemotherapy began in the 1950 s, through exploration, nearly 30 years, until 1988 Buyse [2] issued the first such as colorectal cancer adjuvant chemotherapy was effective (Meta) analysis report, we didnt reach a consensus on the effectiveness of colorectal cancer adjuvant chemotherapy. In recent 10 years, many scholars devoted to colorectal cancer adjuvant chemotherapy drug development and the new design, and carried out a series of large-scale clinical research, colorectal cancer adjuvant chemotherapy so as to make great progress, and gradually changed peoples traditional ideas. Second, the new idea of colorectal cancer adjuvant chemotherapy (1) the concept of biochemical regulation of 5-fu The data suggest that the most effective combination of 5-fu and leucovorin is considered to be the standard treatment for colorectal cancer worldwide. (2) the new ideas for the method of medicine A small dose of prolonged perfusion (PVI) therapy for small doses of 5-fu 5 - Fus time therapy The term therapy refers to the use of drugs for the