贰型糖尿病患者的脂蛋白(a)浓度和载脂蛋白(a)分型(国外英文资料).docVIP

贰型糖尿病患者的脂蛋白(a)浓度和载脂蛋白(a)分型(国外英文资料) The lipoprotein (a) concentration and the apolipoprotein (a) type of diabetic patients 2010-09-06 shi hongli fang-jing Yang xiu-fang, zhu xixing 【 abstract 】 objective to study the patients with type 2 diabetes of lipoprotein (a) [Lp (a)] concentrations and apolipoprotein (a) [apo (a)] polymorphism and the relationship between diabetic chronic complications. Method of this study is to use a modified Utermann and Guo method for 40 non-diabetic controls and 176 patients with type 2 diabetes in apo (a) type test, observe its and Lp (a) the relationship between the concentration and capillaries and major vascular complications, including kidney disease, retinopathy, neuropathy, hypertension, coronary heart disease, cerebral infarction. Results 40 non-diabetic apo (a) types: S3S2, S4 and S4S2 were 20%, 70% and 10% respectively, and serum Lp (a) levels were (0.08 + + 0.07) mg/L. And patients with type 2 diabetes, S2, S3, S3S2, S4, S4S2 and S4S3 frequency were 18.18%, 20.45%, 17.05%, 20.45%, 4.55% and 5.68%, and the concentration of Lp (a) to (0.13 + / - 0.11 mg/L, significantly higher than non-diabetic controls. Compared with without complications of diabetes, diabetic retinopathy, with kidney disease and nerve disease, hypertension, coronary heart disease, cerebral infarction patients of apo (a) fractal distribution frequency have significant differences. Compared with the S2 gene phenotype, the S4 phenotype patients had a significant reduction in fasting blood glucose, 2 hours after meals, and glycosylated hemoglobin levels. The levels of Lp (a) and albumin/creatinine levels were significantly different in different genotypic patients, with S2 being the highest and S3 second, and the S4 lowest. Conclusion in patients with type 2 diabetes and non-diabetic controls of apo (a) gene phenotype distribution of different frequency, the same with and without microangiopathy and the distribution frequency of major vascular complications of dia