严重脓毒症患者低白蛋白血症的相关因素研究.pdfVIP

2012 年4 月第 50 卷第Jl期 ·临床研究· 严重服毒症患者低白蛋白血症的相关因素研究 陈骥 孙小蜒 黄河 广东医学院附属医院危重医学科，广东湛江 524(泊l [摘要]昌的探讨严重版毒血症患者血浆肾上腺髓质素f内皮素-1 值与低自蛋白血症的相关性。方法对我院抬疗的 严重除毒症患者57 例(观察组}及进行健康体检的健康人 57 例(对照组}进行 AM 乎在 ET-J 的检测，肾上腺髓质素的 测定采用非平衡放射免疫法，内皮素斗的测定采用放射免疫分析法，分析两组患者的 AMI ET-l 值与患者低白蛋白 血症的相关性。结果观察组57 例患者的肾上腺髓质索、内皮素-1 的水平均明显高于对照组(P 0.01): 而白蛋白 水平及 AMI ET-l 值则明显低于对照组(P 0.01);严重除毒症患者血浆中的自蛋白水平与I自1 浆中 AMI ET-l 值呈 正相关。结论严重脆毒症患者进行肾上腺髓质素/肉皮素-1 值的测定，可以对怠者病情的严重程度及预后迸行评 估.对l临床治疗提供指导作用。 [关键词p在毒症;肾丰腺髓质素:内皮素-1;低白蛋白血症 [中墨分类号] R459.7 l文革就标坝码J B [文章编号J 1673-9701 (2012 )11 -0039-02 Relevant factors of hypoalbuminemia in patients with severe sepsis CHEN Ji SUN X阳配。略目UANGHe Department of Critical Care Medicìne, Affiliated Hospital of Guangdong MedicaJ College, Zhanjiang 524(用1 ， China [Abstlact] Objective To inv臼tigale the correlation between Ihe 盹rum adrenomedullin (AM)/endolhelin-1 (ET-l) values and tbe hypoalhumínemia in patients wi也配时陀田psis. Meth叫S Fifty-配ven patients WI由 severe 盹psís (the observation group) treated În Ollr hospital and 57 阳lthy examínees (the con回，1 group) received AM and ET-I tests.ηle non-呵uilibrium radioimmunoassay was used to me血ure the adrenomedullin and the radioimmunoassay W画 U睡d 10m臼sure endo由elin- l. ηle correlalion between tbe AM尼T-1 and the hypoalbuminemía in 阴tients of tbe two groups w由副taly配d. Re量ults The adrenomedullin and endothelin-I levels ín the 57 patienls of Ihe observation group were all significantly higher than Ih帽e of the control grollp (P 0.01) , but tbe albumin levels and AM/ET-I values were signific哪tly lower than thOí恒。f tbe control group (P 0.01). The 帽rum albumin levels and serum AMlET-1 values in patients wilh severe sepsís we陀 posìtívely co