进行期银屑病患者皮损中胰岛素样生长因子Ⅰ受体蛋白与mRNA的表达.docx(国外英文资料).docVIP

进行期银屑病患者皮损中胰岛素样生长因子Ⅰ受体蛋白与mRNA的表达.docx(国外英文资料) Active stage was detected in the lesions of psoriasis patients Ⅰ insulin-like growth factor receptor protein and mRNA expression Active stage was detected in the lesions of psoriasis patients Ⅰ insulin-like growth factor receptor protein and mRNA expression Chinese dermatology journal, no. 32, no. 6, 1999 The author: xiao zheng is high in wangs long hair Unit: xiao zheng gao long hair long hair 430022 wuhan, wuhan city first hospital dermatology research room; Wang is affiliated with tongji medical university and the dermatology department of the hospital Keywords: psoriasis receptor and insulin-like growth factor Ⅰ RNA messengers 【 abstract 】 objective to explore the Ⅰ insulin-like growth factor receptor (IGF Ⅰ R) and the relationship between the active stage psoriasis. Methods immunohistochemical technique, reverse transcriptase polymerase chain reaction and in situ hybridization detected in 15 patients with psoriasis and 10 cases of normal skin tissue block IGF Ⅰ R protein and mRNA expression. Results IGF Ⅰ R protein and mRNA expression in psoriatic patients base layer and prickle cell layer, IGF Ⅰ R protein and mRNA relatively integral optical density value in the normal control group with psoriasis extremely significant differences between groups (P 0.01). Conclusion active stage expression was detected in the lesions of psoriasis patients increased IGF Ⅰ R of protein and mRNA may be mediated the formation cutin cell proliferation and differentiation. Insulin-like growth factor Ⅰ (insulin - likegrowthfactor Ⅰ, IGF Ⅰ) is a member of the family of insulin, by the growth hormone, growth hormone, GH) inducing secretion, IGF Ⅰ negative feedback effect on GH, constitute a GH? IGF axis, the axis formed by IGF Ⅰ R ACTS on the cutin cell. We applied the protein and gene detection technology IGF Ⅰ R protein and mRNA expression in active stage with psoriasis. The Expression of Insulin? Like Growth Factor Ⅰ Receptor Protein an