ACTH高兴试验(国外英文资料).docVIP

ACTH兴奋试验(国外英文资料)ACTH test excitedThe ACTH stimulating test for corticosteroid stimulation of adrenal corticosteroid stimulation test (adreno-cortico - tropic hormone)Catalogue 1 pharmacological 2 experimental method 3 clinical significance1, pharmacologicalAdrenocorticotropic hormone (ACTH) can stimulate secretion of adrenal cortex adrenal cortical hormone, including sugar cortical hormone, salt cortical hormone, sex hormones cortical hormone. The metabolites of the hormone 17 - hydroxycorticosteroids (17-ohs) and 17-ketone corticosteroids (17-ks) were excreted in the kidney.This is the introduction of exogenous ACTH test, then the determination of 17 - OHS in blood or urine, 17 - KS or blood eosinophil, through the contrast before and after the test to determine the adrenal cortex function, to differentiate adrenal cortical dysfunction is a primary or secondary.Test method forIn this experiment, there are various experimental methods, such as: one muscle injection method, continuous 48h static injection, two day static drop method, five day static drop method. The second method is commonly used, the adrenocortical hypertrophic disorder can be used in two days of static drops, and the function of hypothyroidism is available for five days.Two days of static drops; 1. Before the test 1, 2, give us 24 h urine determination of 17 - OHS, 17 - KS, smoke or venous blood cortisol, peripheral eosinophil count as a control, can choose according to local conditions of laboratory. The bladder is emptied at 8 p.m., and then the intravenous drip of ACTH, 25u, dissolve in 5% of the glucose 500ml - 1000ml, control the speed, at 8h, for 2 consecutive days. Collect 24h (hour) urine test 17 - OHS, 17-ks, or drip blood serum cortisol, eosinophils.A day of silence; Before the test, the test method, the measuring index and the second day method, are extended to 5 days. The normal human ACTH was excited by the first day of the first day of urine 17-ohs and 17-ks increased by 1 and 2 times