Snake-GVF法和Snake法计算左心室容积的比较研究.docVIP

Snake-GVF法和Snake法计算左心室容积的比较研究 【摘要】 目的：针对心脏核磁共振(MR)图象，分析比较运用Snake-GVF法和Snake法确定左心室(LV)内膜边界， 计算 LV容积的有效性。方法：对27组临床MR图象进行LV容积的计算，包括14名成人（9男5女，平均年龄55.0±23.3岁），3名幼儿（10男3女，平均年龄2.7±2.1岁）。手工勾画法结果作为评价的金标准，将Snake-GVF法与手工勾画法以及Snake-GVF法与Snake法进行线性回归分析，获得直线回归方程与相关系数。结果：Snake-GVF法［y(mL)］与手工勾画法［x(mL)］的回归方程与相关系数为：成人时y=1.008x-0.517和0.996；幼儿时y=1.174x-2.542和0.992。Snake-GVF［x(mL)］法与Snake法［y(mL)］的回归方程与相关系数：成人时y=0.495x+2.301和0.932，幼儿时y=0.637x+1.551和0.912。结论：Snake-GVF法比Snake法更加能够有效地计算心脏MR图象的LV容积。 　　 【关键词】 Snake-GVF法 Snake法 LV容积 　　Abstract Objective: We compared the validation of estimating left ventricular (LV) volumes by Snake with and without gradient vector flow (Snake-GVF) for cardiac cine magnetic resonance imaging (MRI). Methods: 27 sets of clinic MRI data were used, including 14 adults(9men, 5women, 55.0±23.3years ) and 13 children(10boys, 3girls, 2.7±2.1years). LV volumes were calculated by adding the areas surrounded by the extracted contour, and those estimated by manual tracing were considered as a gold standard. Snake-GVF with manual tracing and Snake-GVF with Snake were analyzed by linear regression method. Results: Volumes estimated by Snake-GVF ［y(mL)］correlated well with those estimated by manual tracing［x(mL)］. In adult cases, the regression equation and correlation coefficient were y=1.008x-0.517and 0.996, respectively. In pediatric cases, they were y=1.174x-2.542 and 0.992, respectively. Volumes by Snake are considerably underestimated compared to those estimated by Snake-GVF. In adult cases, the regression equation and correlation coefficient were y=0.495x+2.301and 0.932, respectively. In pediatric cases, they were y=0.637x+1.551 and 0.912, respectively. Conclusion: Snake-GVF can more efficiently calculate LV volume compared to Snake for cardiac cine MRI. 　　Key words Snake-GVF; Snake; LV volume 心脏核磁共振(MR)图象能够对心脏的结构和功能进行准确地描述，是目前无创诊断心脏疾病的重要方法之一。左心室(LV)容积是衡量左心室功能的重要指标之一，对预防、诊断和 治疗 心脏疾病具有非常重要的价值。为了测量LV容积，关键是要确定LV的内膜边界。如果采用手工勾画的方法，简单地用肉眼来确定LV内膜边界是非常困难的，存在较大的主观偏差