荧光量子点探针及其标记技术_蒋飞荣.pdfVIP

DOI:10.13376/j.cbls/2010.04.001 第22 卷 第4 期 生命科学 Vol. 22, No. 4 20 10 年4 月 Chinese Bulletin of Life Sciences Apr., 20 10 文章编号：1004-0374(2010)04-0391-05 荧光量子点探针及其标记技术 1,2# 1# 2 1* 蒋飞荣 ，贾文婷 ，张兴燊 ，任彩萍 （1 中南大学肿瘤研究所，长沙 4 10 0 7 8 ；2 广西中医学院，南宁 5 3 0 0 0 1 ） 摘要：量子点作为一种新型荧光标记物，与有机染料和荧光蛋白质相比，它们具有可调谐且宽的吸收 光谱，激发可产生多重荧光颜色、强荧光信号、抗光漂白能力强等独特的光学特性，使其广泛应用 在生物和医学领域。该文就量子点探针的表面修饰和功能化及其标记技术的研究进展进行了阐述。 关键词：荧光量子点；探针；生物标记 中图分类号：Q 6-33 文献标识码：A Fluorescent quantum dots probes and their biological labeling 1, 2# 1# 2 1 JIANG Fei-rong , JIA Wen-ting , ZHANG Xing-shen , REN Cai-ping * (1 Cancer Research In stitute, Central South University, Changsha 4 10078, China; 2 Guangxi Traditional Chinese Medical University, Nanning 53000 1, China) Abstract: As emerging promising fluorescent labels, semiconductor quantum dots (QDs) have tremendous potential in the fields of biology and medicine because of their unique optical properties with size-tunable light emission, broad absorption spectra for simultaneous excitation of multiple fluorescence colors, superior signal brightness, resistance again st photobleaching, etc . This article briefly discusses the recent progresses on fluorescent QDs probes and their biological labeling including their surface modification and functionalization. Key words: fluorescent quantum dots; probe; biological lab