链球菌进化改良.pdfVIP

TIMI-760; No. of Pages 6 Opinion Evolution of a new signal transduction pathway in Candida albicans David R. Soll Department of Biology, The University of Iowa, Iowa City, IA 52242, USA The evolution of new signal transductions pathways is to have derived all of its upstream components from a poorly understood. Here I present a rare glimpse into the conserved ancestral pheromone response pathway for the evolution of one such pathway, namely the white-cell mating process [15], the transcription factor that the up- pheromone response pathway in Candida albicans. In stream pathway activates from a conserved and ancestral this pathway, the upper portion has been derived intact filamentation or biofilm pathway [17], and the genes spe- from the ancestral pathway for mating, the targeted cifically upregulated by the transcription factor from a transcription factor from an ancestral filamentation or conserved ancestral program for biofilm formation [16]. biofilm pathway, and the upregulated genes from an Here I explore the hypothesis that a signal transduction ancestral biofilm pathway. Each component of this path- pathway can evolve in a new cell type by borrowing the way, therefore, has been derived from a conserved path- upstream components of a co-regulated pathway in a way. I suggest that the evolution of this new pathway conserved cell type that the new cell type has evolved to provides one possible paradigm for the evolution of facilitate, and downstream components from processes other signal transduction pathways in new cell types. with a phenotypic outcome that provides such facilitation. Borrowing portions of conserved pathways