氨基酸衍生物介入的支化聚乳酸的合成研究.pdfVIP

第24 卷 第1 期 天 津 农 学 院 学 报 Vol. 24 ，No. 1 2017 年3 月 Journal of Tianjin Agricultural University March ，20 17 文章编号：1008-5394 （2017 ）0 1-0062-04 氨基酸衍生物介入的支化聚乳酸的合成研究 杨延波，李恒，潘虹通信作者 ，石军，赵蔚鑫 （天津农学院 基础科学学院，天津 300384 ） 摘 要： 由于线型聚乳酸具有结晶度高 、细胞亲和性差、加工成型困难等缺点，因此本研究以 N,N- 二（2-羟丙基）甘氨酸（BHPG ）作为支化单体和催化剂，引发丙交酯发生开环聚合反应，制备出 支化聚乳酸。通过乙二醛和二异丙醇胺之间的亲和加成反应制备 BHPG ，并采用 FT-IR、1H NMR 表征了兼具支化单体和催化剂的 BHPG ；然后引发丙交酯开环聚合制备支化聚乳酸，所得聚合物用 GPC 进行表征；并推测了氨基酸衍生物介入的制备支化聚乳酸的反应机理。 关键词：氨基酸衍生物；支化聚乳酸 ；反应机理 ；催化剂 中图分类号：O631.5 文献标识码 ：A Synthesis of Branched Polylactide Mediated by Aminoacid Derivative YANG Yan-bo, LI Heng, PAN HongCorresponding Author, SHI Jun, ZHAO Wei-xin （College of Basic Science, Tianjin Agricultural University, Tianjin 300384, China ） Abstract: Due to high crystallinity, poor cell affinity and difficult processing, the branched polylactide was successful synthesized by the Ring Opening Polymerization （ROP ）of lactide initiated with N,N-Bis- （2-hydroxypropyl ）glycine as branched monomer and catalysts in this paper. The nucleophilic addition reaction between oxalaldehyde and diisopropanolamine was performed to prepare BHPG characterized by FT-IR 、1H NMR. Then, the ROP reaction of lactide was initiated by BHPG to obtain the branched polylactide. The obtained polymers were characterized by GPC. Finally, the mechanism of reaction, which was being mediated with amino derivative, was clarified. Key words: aminoacid derivative; branched polylactide; mechanism; catalyst 目前，脂肪族聚酯因其良好的生物降解性和 此，通过选择合适的支化剂和高效、无毒催化剂， 生物