泛素-蛋白酶体通路与癌症关系研究进展.pdfVIP

- 201018 -UPP UPP UPP -UPP - ( ubiquitin-pro-teasome pathway, UPP) - 26SUPP 1.-UPP UPP( ubiquitin, Ub)( ubiquitin-activatingenzyme, E1) ( ubiquitin-conjugatingenzyme, E2) ( ubiquitin-protein ligating enzyme, E3) 26S( deubiquitinating enzyme, DUBs)UPP 1.1( ubiquitin, Ub) 1975Goldstein [1] 3 768.5 10 ATP E1Ub E1 Ub UbE2E2E3 UbUb UbUb4Ub 1.2( ubiquitin-activating enzymes, E1) 3 3 11010 11710 2 C 1.3( ubiquitin-conjugating enzymes, E2) 1435 150 E1E3E2E2E2E3 1.4-( ubiquitin-protein ligases, E3) -HECT( homologous to E6-associated protein car-boxy1 terminus)( RING finger)U-box E3 - 1.5 26SATP20S19S 11S 1.5.1 20S( core protease, CP) CP426S 20S 2 2NCP 1.5.2 11S( regulator, REG) 3 11S328 10 1734R