海洋抗肿瘤药物临床研究进展.pdfVIP

海洋抗肿瘤药物的临床研究进展 Progress in the clinical development of marine-origi- nated antitumor drugs 1 1 1 2 , , , (1. , 222005; 2. , 266071) : R931.77 : A : 1000-3096(2010)03-0082-06 , DNA , ; ET-743 , [2] , , () Ⅱ, ET-743 , , , [3,4]; 3 189 Ⅱ , , ET-743 50% , (Ara-C) , , 10.3 , 19.8% 20 , 6 , 29.3%2 ET-743 ET-743 , (dose-limiting toxicity, DLT) 1 进入Ⅲ期临床实验的药物 , , [5] 1.1 Ecteinascidin 743 (ET-743, ET743, Trabectedin, NSC 684766, Yondelis) , ET-743 , [6, 7] Ⅲ, ET-743 ET-743 Ecteinascidia FDA turbinate 1990 Reinhart [1]E. turbinate ET-743 ET-743( Yondelis) , Scott [2] ET-722 736, ET-743 1.2 E7389(NSC 707389) ET-743 ,