空腹血胰岛素、葡萄糖比值作为β细胞功能指数的可能性(国外英文资料).docVIP

空腹血胰岛素、葡萄糖比值作为β细胞功能指数的可能性(国外英文资料) The ratio of fasting blood to insulin and glucose is the potential of the beta cell function index 2010-02-23 li guangwei pan filial piety 【 abstract 】 objective to investigate the fasting plasma insulin and glucose ratio (FINS/FPG) as a group to study the possibility of islet beta cell function index, and compared with other index in the literature. Method in normal glucose tolerance (NGT) 181 cases, person that low to reduce glucose tolerance (IGT), 281 cases of determination and take 75 grams of glucose on an empty stomach 1 hour, 2 hours after venous plasma glucose and insulin. According to 2 hours after taking sugar blood glucose levels, in turn, increasing tendency for 0.556 / L, then IGT is divided into 6 subgroups from low to high blood sugar, by t test and variance test determine FINS/FPG and five islet beta cell function is commonly used in the literature index to distinguish NGT with IGT, and IGT blood sugar levels ss-cell function of the difference between different subgroups. Results (1) OGTT 1-h plasma insulin and glucose ratio (INS1 / PG1), OGTT insulin, blood sugar value ratio (delta INS/delta PG) and Homa model of 20 x FINS/(FPG 3.5) can distinguish from NGT, IGT ss-cell function changes, but none can recognize different subsets of IGT blood sugar level difference of beta cell function. After adjusting the effects of insulin sensitivity, they were able to distinguish between the various levels of beta-cell function. Conclusions the effects of insulin sensitivity must be adjusted by using the beta cell function index. The FPG can evaluate the function of beta cells in an epidemiological study, which is not inferior to the 20 x FINS (fpg-3.5) in the Homa model. 【 keywords 】 sugar tolerance reduces beta-cell function insulin blood sugar The Possibility of using the fasting blood insulin/glucose thewire as an index of beta cell functionLi Guangwei, Pan Xiaoren. Department of Endocrinology, China - Japan Friendship Hosp