miRNA-7全文.pdf

1521-0111/83/4/857–869$25.00 /10.1124/mol.112.082743 MOLECULAR PHARMACOLOGY Mol Pharmacol 83:857–869, April 2013 Copyright ª 2013 by The American Society for Pharmacology and Experimental Therapeutics Lapatinib-Mediated Cyclooxygenase-2 Expression via Epidermal Growth Factor Receptor/HuR Interaction Enhances the Aggressiveness of Triple-Negative Breast Cancer Cells s Te-Chun Hsia, Chih-Yen Tu, Yun-Ju Chen, Ya-Ling Wei, Meng-Chieh Yu, Sheng-Chie Hsu, Shing-Ling Tsai, Wen-Shu Chen, Ming-Hsin Yeh, Chia-Jui Yen, Yung-Luen Yu, Tzung- Chi Huang, Chih-Yang Huang, Mien-Chie Hung, and Wei-Chien Huang Graduate Institutes of Integrated Medicine (T.-C.Hs.), Cancer Biology (M.-C.Y., S.-L.T., W.-S.C., Y.-L.Y., M.-C.H., W.-C.H.), and Basic Medical Science (C.-Y.H.), Departments of Internal Medicine (C.-Y.T.) and Biomedical Imaging and Radiological Science (T.-C.Hu.), and the Ph.D. Program for Cancer Biology and Drug Discovery (Y.-L.Y., W.-C.H.), China Medical University, Taichung, Taiwan; Department of Medical Research, E-DA Hospital, Kaohsiung, Taiwan (Y.-J.C.); Department of Biological Science and Technology, I-Shou University, Kaohsiung, Taiwan (Y.-J.C.); Center for Molecular Medicine (Y.-L.W., S.-C.H., Y.-L.Y., M.-C.H., W.-C.H.), Department of Internal Medicine (T.-C.Hs., C.-Y.T.), Division of Pulmonary and Critical Care Medicine (C.-Y.T.), Section of Breast Surgery (M.-H.Y.), China Medical University and Hospital, Taichung, Taiwan; Department of Life Science (C.-Y.T.), National Chung-Hsing University, Taichung, Taiwan; Internal Medicine, National Cheng-Kung University, Tainan, Taiwan (C.-J.Y.); Dep