血小板抗原与抗体的研究及其应用.pdfVIP

• 466 • Int J Blood Transfus Hemato! November 2016. Vo I. 39. No.6 ·专圭窘~te;垣王· 血小板抗原与抗体的研究及其应用 许先国 310052 杭州，浙江省血液中心国家卫生计生委血液安全研究重点实验室 通信作者:许先固，EmaiI: yjs001@163.com DOI: 10.3760/cma. j. issn. 1673-419X. 2016.06.002 E摘要E 血小板抗原与抗体的研究，在各类免疫性血小板减少症的诊断和治疗中具有重要作用。与红 细胞血型遗传和免疫血液学技术相比，血小板抗原、抗体的基础研究和免疫检测技术相对落后，尤其是国 内，在新的种族特异性血小板抗原的发现、血小板抗体特异性鉴定、血小板输注同种免疫问题等方面，亟需 加大研究力度，以推动我国血小板免疫学研究和临床应用的发展。 E关键词】 抗原，人血小板; 抗体; 输血 基金项目 2 国家自然科学基金项目 ; 国家卫生计生委省部共建项目 (WK]-Z]-1510) Research and application of platelet antigens and antibodies Xu Xianguo Blood Center of Zhejiang Provínce , Key Laboratory of Blood Safety Research. MOH , Hangzhou 310052 , Zhejiang Province , China Corres户onding author: Xu Xianguo , Email: yjsOOl@163.com (Abstract The studies of platelet antigens and antibodies play an important role in the diagnosis and treatment of various immune thrombocytopenias. The level of basic research and immune technology on platelet antigens and antibodies is relatively backward compared with the blood group genetics and immunohematology on red blood cells. Especially in China , mOre studies should be done on platelet immunology , such as discovery of novel ethnicity-specific platelet antigens. antibodies identi日cation. and immune problems on platelets transfusion. to promote the development of platelet immunology and clinical application in our country. (Key words Antigens. human platelet; Antibodies; Blood transfusion Fund programs: National Natural Science Foundatìon of China ; Provìnce-Mînistry Co-constructed Project of Natîonal Health and Family Planning Commission (WKJ-Z]-1510) 有效的血小板输注，可提高患者血小板计数，改善 1 血小板表面的抗原系统 止血效果，降低出血风险。近年随着血液供求紧张，血 小板 ABO 血型非同型输注备受关注和争论，其焦点