射频消融术联合化疗与手术联合化疗治疗声门型喉癌效果对比.docVIP

射频消融术联合化疗与手术联合化疗治疗声门型喉癌的效果对比 　　[摘要] 目的 比较射频消融术（RFA）联合化疗与手术联合化疗治疗声门型喉癌的临床效果。 方法 选择2013年12月～2014年12月武警陕西总队医院收治的声门型喉癌患者92例，采用简单随机法将患者分为对照组与观察组，每组各46例。对照组患者给予手术联合化疗治疗，观察组患者给予RFA联合化疗。对治疗后两组患者的临床疗效、生活质量KPS评分、不良反应发生率、肿瘤细胞凋亡率、术后复发情况及存活率进行比较。 结果 治疗后，观察组临床治疗有效率及临床症状控制率均高于对照组，两组比较差异有统计学意义（P 0.05）。结论 对声门型喉癌患者进行RFA联合化疗治疗，可明显提高临床疗效、生活质量及肿瘤细胞凋亡率，减少不良反应，值得临床推广与应用 [关键词] 射频消融术；化疗；声门型喉癌；临床疗效；不良反应 [中图分类号] R739.65 [文献标识码] A [文章编号] 1673-7210（2016）07（b）-0100-04 [Abstract] Objective To compare clinical efficacy of radiofrequency ablation combined with chemotherapy and surgery combined with chemotherapy in the treatment of glottic carcinoma. Methods Totally 92 patients with glottic carcinoma in Shaanxi General Hospital of CAPF from December 2013 to December 2014 were randomly divided into observation group and control group by simple random method， with 46 cases in each group. Control group was treated by surgery combined with chemotherapy， while observation group was treated by radiofrequency ablation combined with chemotherapy. Clinical efficacy， KPS scores， the incidence of adverse reaction， apoptosis rate， recurrence rate and the survival rate of patients in the two groups were compared. Results After the treatment， clinical efficacy of patients in the observation group after treatment was significantly higher than that in the control group， the difference was statistically significant （P 0.05）. Conclusion Radiofrequency ablation combined with chemotherapy in treatment of glottic carcinoma can enhance clinical efficacy， life quality and the apoptosis rate， and reduce the incidence of adverse reaction. It is worthy of clinical application. [Key words] Radiofrequency ablation； Chemotherapy； Glottic carcinoma； Clinical efficacy； Adverse reaction 　　喉癌是头颈部肿瘤中最为常见的恶性肿瘤之一，发病率仅次于鼻咽癌和鼻窦癌，而声门型喉癌是喉癌中较为常见的肿瘤，占喉癌的50%～70%[1]。近年来其发病率呈现出明显上升的趋势，但由于早期症状类似于咽炎，很难引起患者的注意，当临床症状严重时，往往已进入中晚期，往往失去最佳治疗时机。因此，对其进行早发现，早治疗，对于提高患者的生存率具有重要意义[2-3]。近年来开展的射频消融术（radiofrequency ablation，RFA）是一项微创性的介入治疗方法，可用