卡泊三醇治疗寻常型银屑病的回顾.pdfVIP

中国中西医结合皮肤性病学杂志2012 年第 11 卷第6 期 · ·· · 341 ·论著· 0.005%卡泊三醇软膏治疗寻常型银屑病文献回顾 任发亮，常宝珠，陈旭，黄丹，顾恒 （中国医学科学院北京协和医学院皮肤病医院，南京210042） 摘要：目的 回顾国内卡泊三醇软膏治疗寻常型银屑病的临床文献，总结其治疗效果。方法 检索和阅读卡泊三醇 软膏自 1995 年开始国内应用至 2011 年治疗寻常型银屑病随机、对照的临床研究文献，整理和分析其有效性和安全 性。结果 单用卡泊三醇软膏的总有效率分别为 43.3%（4 周），75.8%（6 周），45.1%（8 周），77.6%（12 周）。可统计的不 良反应率为 15.70%。偶见实验室指标异常。单用与他扎罗汀凝胶、哈西奈德乳 膏、蒽林软膏、骨化三醇软膏相当 ，逊于 他克莫司软膏、钙泊三醇倍他米松软膏。联合、序贯、封包等方法提高疗效、降低不良反应。结论 卡泊三醇软膏治疗寻 常型银屑病安全、有效，联合、序贯、封包可优化治疗结果。 ： 关键词 卡泊三醇 ；银屑病 ；寻常型 ： （ ） 中图分类号：R758.63 文献标识码 A 文章编号：1672－0709 2012 06-0341－04 0.005% Calcipotriol Ointment in the Treatment of Psoriasis Vulgaris in China REN Faliang, CHANG Baozhu, CHEN Xu, HUANG Dan, GU Heng Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China ： Abstract Objective To summarize the experience of calcipotriol in treatment of psoriasis vulgaris. Methods We evaluated data on the efficacy and safety of 0.005% calcipotriol topically used in psoriasis vulgaris retrieved from China BioMedical Literatures Database （CBM）, covering the period from 1995 to 2011. Only patients reported in the Chinese literature were included in this review. Results Total effective rates of Calcipotriol Ointment topically used only were 43.3% with duration for four weeks, 75.8% for six weeks, 45.1% for eight weeks, 77.6% for 12 weeks respectively. Available adverse reaction occurrence rate was 15.70% in monotherapy appliance, and abnomal laboratory examination was occationally examined. The effects of calcipotriol Ointment