质子泵抑制剂不良反应文献分析_王安起.pdf

中国药物警戒第10卷第11期 2013年11月 November,2013,Vol.10,No.11 中图分类号：R975;R994.11 文献标识码：A 文章编号：1672-8629（2013）11-0683-04 质子泵抑制剂不良反应文献分析 王安起（北京市顺义区中医医院，北京101300） 摘要：目的总结质子泵抑制剂不良反应的规律和特点，为临床合理用药提供参考。方法检索CHKD全文数据库，对 2008～2012年报道的质子泵抑制剂不良反应病例进行统计分析。 涉及质子泵抑制剂不良反应的文献30篇，报 结果 道例数34例；不良反应累及多个系统-器官，临床症状复杂多样，不良反应症状均比较严重，而且临床上属少见 及罕见，经停药处理后预后较好。结论加强对该类药品不良反应的认识，注意防范，合理选用质子泵抑制剂。 质子泵抑制剂；药品不良反应；分析 关键词： WANG An-qi (Traditional Chinese Medicine Hospital of Shunyi District, Beijing 101300, China) Abstract:ObjectiveTo summarize the regularity and characteristics of adverse drug reaction(ADR) induced by proton pump inhibitors, and provide reference for the rational use of drugs in clinic. MethodsRelated literatures of ADR ～ induced by proton pump inhibitors were collected from CHKD full-text database during 2008 2012, then the included literatures were statistically analyzed. ResultsA total of 30 literatures relating to ADR induced by proton pump inhibitors were collected, including 34 cases. This group of ADR induced by proton pump inhibitors involved multiple system-organs, the clinical signs were complex and varied, and symptoms of adverse drug reactions were relatively serious, and rare in clinic, but prognosis was good after stopping drug treatment. ConclusionWe should strengthen the understanding of these types of adverse drug reactions, pay attention to the prevention and improve the rational use of proton pump inhibitors. Keywords:proton pump inhibitors; adverse drug reaction; analysis 质子泵抑制剂在临床上广泛用于胃及十二指肠溃 种类、临床表现。 疡、反流性食管炎、卓-艾综合征及与抗生素根除幽门 2 结果 螺杆菌等。随着临床使用的增加，除常见的反应外，一些 2.1一般资料 少见的以至罕见的不良反应（ADR）也逐渐被报道，涉及 2.1.1 年龄与性别 在34例中，男性18例，女性16例。 机体多个系统，且临床表现较重，若缺少足够的临床认 年龄最大者为87岁，最小20岁。其中20～40岁12例， 识、诊断及处理不当，可导致严重损害。本文汇总分析近 41～60岁12例，60岁以