快速崩解配方研究-崩解剂.pdf

Md. Mofizur Rahman et al. / International Journal of Pharma Sciences and Research (IJPSR) Vol.2(2), 2011, 84-92 EFFECT OF MODE OF ADDITION OF DISINTEGRANTS ON DISSOLUTION OF MODEL DRUG FROM WET GRANULATION TABLETS 1* 2 3 3 Md. Mofizur Rahman , Sumon Roy , Sayeed Hasan , Md. Ashiqul Alam , Mithilesh Kumar Jha1, Md. Qamrul Ahsan4 and Md. Jannatul Ferdaus5 1Department of Pharmacy, Bangladesh University, Dhaka, Bangladesh, 2Department of Pharmacy, Southeast University, Dhaka, Bangladesh, 3Department of Pharmaceutical Technology, University of Dhaka, Bangladesh, 4Department of Pharmacy, Southern University, Bangladesh, 5Department of Pharmacy, Primeasia University, Dhaka, Bangladesh ABSTRACT The purpose of the study was to formulate immediate release tablets using various types of disintegrants (crospovidone, sodium starch glycolate and sodium carboxymethylcellulose), in order to investigate the effect of mode of incorporation of disintegrants on release mechanism from tablets. Acetaminophen, a poor soluble drug was used as a model drug to evaluate its release characteristics from different formulations. The USP paddle method was selected to perform the dissolution profiles carried out by USP apparatus 2 (paddle) at 50 rpm in 900 ml phosphate buffer pH 5.8. Successive dissolution time, time required for 25%, 50% and 80% of the drug release (T25%, T50%, T80%) was used to compare the dissolution results. A One way