马兰教授：科研论文的特点,构思和发表过程.ppt

科研论文的特点、 构思和发表过程 科研能力的培养 怎样衡量科研能力和水平？ 基础研究的成果以论文形式表现 发表论文的质量与数量是衡量科研工作者水平和效率的一个客观标准 科学论文 公开发表的、描述新研究结果的书面报告；必须按一定的方式撰写和发表 论文必须： 是新研究结果的首次公布 以同行能够重复实验、验证结论的形式发表 发表在同行很容易得到的刊物上（同行评议杂志上） 撰写和发表论文是科研工作的最后一道工序，科学研究的结果必须发表 “Publish or Perish” 不仅要“做”研究，还必须“写”研究、 “讲”研究 论文构思、形成和发表的过程 论文的基本结构（IMRAD） Introduction: 研究什么问题？为什么研究这个问题？ Methods：如何研究的？ Results：发现了什么？ Discussion：发现意味着什么？ 标 题 重要性和创新点 包含所有关键词 （检索） 吸引人 用动词、句子 Heterologous activation of protein kinase C stimulates phosphorylation of d-opioid receptor at serine 344 and this results in beta-arrestin- and clathrin-mediated receptor internalization. J Biol Chem Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates. J. Neurosci. Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation and this is mediated through interaction of trichosanthin and chemokine receptor. J Exp Med Inhibition of CamK II in rat hippocampus attenuates morphine tolerance and dependence. Mol Pharmacol. Carboxyl terminus of delta opioid receptor is required for agonist-dependent receptor phosphorylation. Biochem Biophys Res Commun N-methyl-D-aspartate attenuates opioid receptor-mediated G protein activation and this process involves protein kinase C. Mol Pharmacol. 词组 Identification of G protein-coupled receptor kinase 2 phosphorylation sites responsible for agonist-stimulated delta-opioid receptor phosphorylation. Mol Pharmacol Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase. J Biol Chem Selective interference of b-arrestin 1 with k and d but not m opioid receptor/G protein coupling. J Biol Chem. Retardation of pain development: a case of recovery from congenital insensitivity to pain. Acta Anaesthesiol Scand 类似的研究 Differential regulation of beta-arrestin 1 and beta-arrestin 2 gene expression in rat brain by morphi