激素水平与慢性病的关联性讨论.pdfVIP

Hindawi Publishing Corporation International Journal of Chronic Diseases Volume 2015, Article ID 927974, 7 pages /10.1155/2015/927974 Research Article Female Sex Hormones Pattern and Its Relation to Disease Severity and Treatment in Pre- and Postmenopausal Patients with Chronic Hepatitis C Virus (Genotype 4) Infection Nora H. Ahmed,1 Taghrid B. El-Abaseri,1 Hesham F. El-Sayed,2 and Taher I. El-Serafi1 1 Department of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia 41111, Egypt 2Department of Pediatrics and Unit of Clinical Epidemiology, Faculty of Medicine, Suez Canal University, Ismailia 41511, Egypt Correspondence should be addressed to Nora H. Ahmed; nour fomscu@ Received 22 June 2015; Revised 4 August 2015; Accepted 5 August 2015 Academic Editor: Tadeusz Robak Copyright 漏 2015 Nora H. Ahmed et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Chronic hepatitis C (CHC) course revealed diferences between men and women. Male gender and postmenopausal women are thought to be of the critical factors afecting HCV infection progression. he study aimed to assess female sex hormones and their relation to disease severity and treatment in HCV infected females. Subjects were divided to 2 groups: 44 CHC female patients and 44 controls. Both groups were classiied to premenopausal and postmenopausal females. Serum estradiol (E2), progesterone (PRG), and total testosterone (TT) were assessed using chemiluminescent immunoassay. Our results showed that menopausal patients had signiicantly higher levels of estradiol, total testosterone, and progesterone compared to controls (肀 0.001). Reproductive aged