多发性硬化 ,视神经脊髓炎.pdf

Multiple Sclerosis and Related Disorders (2013) 2, 103–108 Available online at journal homepage: /locate/msard A pilot MRI study of white and grey matter involvement by multiple sclerosis spinal cord lesions a,n b a H. Kearney , K.A. Miszkiel , M.C. Yiannakas , O. Ciccarellia, D.H. Millera aNMR Research Unit, Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, London, UK bDepartment of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, UK Received 3 July 2012; received in revised form 30 August 2012; accepted 12 September 2012 KEYWORDS Abstract Multiple sclerosis; Objectives: Spinal cord pathology is a major cause of disability in multiple sclerosis (MS) and Spinal cord lesions; pathology studies show multifocal demyelinating lesions in white matter (WM) tracts and MRI; central grey matter (GM). Better localisation of cord lesions by in vivo MRI may help to White matter; understand the structural–functional effects of spinal cord pathology in MS. Grey matter; Methods: Three-Tesla MRI was performed on upper cervical cord in 15 MS patients and one Spinal cord pathology clinically isolated syndrome. Axial 3D gradient-echo fast field echo (3D-FFE) and phase sensitive inversion recovery sequences (3D-PSIR) were acquired. Two readers reviewed images to detect and classify lesions: WM-only, mixed WM–GM or GM-only. Location of the WM component was classified: