糖尿病回并高血压对微血管病变患病率的影响.docVIP

糖尿病合并高血压对微血管病变患病率的影响 糖尿病合并高血压对微血管病变患病率的影响 2009-12-14 陈玉堂　田慧 　　【摘要】　目的　为了解糖尿病合并高血压对微血管病变患病率的影响。方法　对325例2型糖尿病合并与不合并高血压对糖尿病微血管病变患病率的影响进行了回顾性分析。结果　2型糖尿病合并高血压组糖尿病肾病(DN)、糖尿病视网膜病变(DR)、糖尿病周围神经病变(DPN)和糖尿病自主神经病变(DAN)的患病率分别为61.32%、49.06%、45.28%和24.53%，均高于血压正常组(患病率分别为27.85%、29.68%、32.42%和15.53%。有关影响因素拟合Logistic逐步回归方程分析，结果显示糖尿病病程是DN、DR、DPN和DAN患病的共同影响因素。高血压是DN、DPN患病的危险因素(OR值分别为2.59、2.55，P值分别为＜0.01、＜0.05)。结论　糖尿病合并高血压将增加糖尿病微血管病变的患病率。 　　【关键词】　2型糖尿病　　糖尿病微血管病变　　肾病　　视网膜病变　　周围神经病变　　自主神经病变 Effect of diabetes with hypertension on the prevalence of diabetic microvascular complications Chen Yutang,Tian Hui.General Hospital of PLA,Beijing,100853 　　【Abstract】　Objective　To investigate the effect of diabetes with or without hypertension on the prevalence of diabetic microvascular complications. Methods　325casesoftype2diabetesmellituswere studied retrospectively and the effects exerted by complicating hypertension were classified. Results　The prevalences of diabetic nephropathy (DN, 61.32%), retinopathy (DR, 49.06%), peripheral neuropathy (DPN, 45.28%) and autonomic neuropathy (DAN, 24.53%) in the hypertensive group were higherthan those in the normotensive group (DN 27.85%, DR 29.68%, DPN 32.42% and DAN 15.53%). The analysis with Logistic stepwise regression showed that lengthened diabetic course was the common risk factor for DN, DR, DPN and DAN. Hypertension affected mainly DN, DPN (Odds ratio being 2.59 and 2.55 respectively, P＜0.05). Conclusion　Diabetes mellitus complicated with hypertension increased the prevalence of diabetic microvascular complications. 　　【Key words】　Diabetes mellitus, type 2　　Diabetic microvascular complication　　Nephropathy　　Retinopathy　　Neuropathy (Chin J Endocrinol Metab, 1998, 14:106-108) 　　糖尿病合并高血压将加重大血管壁粥样硬化的形成，使心脑大血管病变的患病率显著增加。为了解合并高血压是否会加重糖尿病微血管病变的发生发展，本文对我院收治的325例2型糖尿病患者合并微血管病变如糖尿病肾病(DN)、糖尿病视网膜病变(DR)、糖尿病外周神经病变(DPN)和糖尿病自主神经病变(DAN)的有关情况作回顾性分析。 材料和方法 　　一、病例来源 　　我院1993～1995年间在内分泌科住院的2型糖尿病患者325例。详细记录每例年龄、性别、身高、体重、初入院时糖基化血红蛋白(HbA1c)水平，糖尿病病程及家族史，高血压病病程及家族史，