纯真高血压及出缺血性脑卒中并发症患者纤溶系统的观察迟疑.docVIP

单纯高血压及有缺血性脑卒中并发症患者纤溶系统的观察 单纯高血压及有缺血性脑卒中并发症患者纤溶系统的观察 更新日期： 12-02 芦海　朱栓立　王焕文　戴庆麟　邢万忠　徐航　邓宇　李淑荣 摘　要：目的　观察高血压伴或不伴缺血性脑卒中患者的纤溶系统的变化。方法　观察了47例高血压伴缺血性脑卒中患者和20例无缺血性脑卒中的高血压患者纤溶系统的变化，并与24例健康对照组进行了比较。结果　高血压伴缺血性脑卒中患者t-PA和纤溶酶原明显低于单纯高血压组(P＜0.05)和健康对照组(P＜0.01)；而PAI和D-二聚体及纤维蛋白原明显高于高血压病患者(P＜0.05)和健康对照组(P＜0.01)；单纯高血压病患者t-PA和纤溶酶原明显低于健康对照组(P＜0.05)，而PAI和D-二聚体及纤维蛋白原明显高于健康对照组(P＜0.05)。结论　高血压病患者存在有血纤溶功能异常，尤以高血压伴缺血性脑卒中患者更为明显。血栓形成和血纤溶功能异常可能在急性缺血性脑血管病发病过程中起着重要的作用。 关键词：高血压　缺血性脑卒中　纤溶系统 Observation of fibrinolytic system in hypertension and hypertensive patients with ischemic stroke Lu Hai (Institute of Hypertension and diabetes, Jiuxianqiao Hospital of Beijing, Beijing 100016) Zhu Shuanli (Institute of Hypertension and diabetes, Jiuxianqiao Hospital of Beijing, Beijing 100016) Wang Huanwen, et al (Institute of Hypertension and diabetes, Jiuxianqiao Hospital of Beijing, Beijing 100016) Abstract：Abjective 　 Observed the alteration of fibrinolytic system in hypertensiv patients with ischemic stroke and twenty cases of hypertensive patients. Results　 t-PA and plasminog-en(PLg) were significantly lower in hypertensive patients with ischemic stroke than in hypertension group and healthy control group, but PAI and D-D and fibrinogen(FbG) were significantly higher in hypertensive patients with ischemic stroke than in hypertension group and healthy control group. Thet t-PA and PLg were significantly lower in hypertension group than in healthy control group, but PAI and D-D and FbG were significantly higher in hypertension group than in healthy control group. Conclusion　 There were abnormal fibrinolytic activities in patients with hypertension, especially in hypertensive patinents with ischmic stroke. Key words：Hypertension　 Ischemic stroke 　Fibrinolytic system▲ 　　血液中具有强大的抗凝系统，特别是纤溶系统发挥溶解业已形成的纤维蛋白的作用。当纤溶系统活性降低时，就容易形成血栓，而血栓形成是缺血性脑卒中发生的重要原因。本研究目的是观察高血压及缺血性脑卒中患者纤溶功能的变化。 对象和方法 　　1.研究对象：分为三组：①单纯高血压组：为门诊确诊的原发性高血压病患者，无缺血性脑卒中，共20例，男10例，女10例，平均年龄57.10±7.43岁(42～68岁)，体重指数25.70±2.74kg/m2；②高血压伴缺血性脑卒中组