斯沃治疗革兰阳性球菌相关研究.ppt

* On the cover: “The Sick Child.” Photograph ? Hamburger Kunsthalle, Hamburg, Germany/Bridgeman Art Library. Reproduced with permission. This painting, titled “The Sick Child,” was made by a French painter named Jean Augustin Franquelin (1798–1839). The anxious mother watching over her ill child is depicted in a rustic setting and wears brightly colored peasant clothes that contrast with her expression of deep concern, verging on despair. The artist has placed a single tear below the mothers left eye. This painting is from the same decade as a work (“The Sick Child”) by the British painter Edward Bird that appeared previously in the 1 January 2005 issue of the journal but is much more stylized in execution. The artist demonstrates his skills in depicting many kinds of textures and surfaces, such as the deteriorating plaster and brick wall, the basketry of the childs crib, the smoke from the lamp behind the mothers head, and the shiny brass kettle. The cloth in the basin is a poultice that the mother has applied to the childs head in an attempt to treat the infection. Genre paintings about intimate, emotional subject matter and using “realistic” technique remained popular throughout the 19th century. The painting is in the collection of the Hamburger Kunsthalle, Hamburg, Germany. (Ann Arvin, Cover Art Editor) Close 此研究的评价标准包括微生物学评价及临床疗效评价，并未包括病死率的比较；此外，利奈唑胺是仅针对G+菌感染的抗菌药物；因此，若仅评价利奈唑胺治疗G+菌所致导管相关感染的疗效，其结果又将如何？ 对于本研究的思考 由G+菌所致导管相关感染患者 ITT (n=363) 入选患者(n=739) 利奈唑胺(n=368) 对照组(n=367) 数据不准确(n=4) ITT (n=363) 未接受研究所用抗菌药物 (n=5) (n=4) MITT (n=269) MITT (n=257) 非G+菌感染患者 (n=94) (n=106) ME-1 (n=193) ME-1 (n=189) 不符合6项评估标准 (n=76) (n=68) MME-1 (n=164) MME-1 (n=151) 管尖仅分离到CoNS或病原体不相同 (n=29) (n=38) ME-2 (n=95) ME-2 (n=74) 外周血及导管所分离到病原体不相同 (n=69) (n=77) 患者分组 接受治疗者 培养阳性者 可评估人群 cSSSI CRBSI cSSSI：复杂性皮肤软组织感染；CRBSI：导管相关血流感染； ITT：意向评估人群；MITT：修正意向评估人群； ME：微生物学可评估人群；MME：修正微生物学可评估人群； CoNS：凝固酶阴性葡萄球菌。 cSSSI CRBSI MME-1 (n=164) ME-2 (n=95) MME-1 (n=151) ME-2 (n=74) Wilcox MH et al. Clinical Infect