抑癌基因P27在急性白血病中作用研究进展.pdf

http: / /www. b iother. org 354 Ch in J Cancer B iother, Jun. 2010, Vol. 17, No. 3 DOI: 10. 3872/ j. issn. 1007385X. 2010. 03. 022 综述 P27 1 1, 2 汤宏宇综述; 何 勤 审阅 ( 1. 昆明医学院第二附属医院血液科, 2. 昆明医学院 第二附属医院 内科学教研 室, 云南昆明 50101) [ ] P 27 , ( cyclindependent kinase inh ib itor, CDK Is) , P27 P2 7 , P27 P27 , P27P2 7 DNA , P2 7 , P27 , [ ] P 27 ; ; ; DNA [ ] R733. 71; R730. 2 [ ] A [] 1007385X( 2010) Roles of tumor suppressor geneP27 in acute leu em ia 1 1, 2 TANG H ongyu , HE Q in ( 1. Departm ent of H em atology, Second A ffiliated Hosp ital of Kunm ing M ed ical College, Kunm ing 50101, Yunnan, China; 2. Departm ent of InternalM ed icine, Second A ffiliated Hospital of Kunm ing M ed ical College, Kunm ing 50101, Yunnan, China) [Abstract] P27, a new ly identified tumor suppressor gene, belongs to cyclindependent kinase inh ibitors ( CDK Is) fam ily. A s a negative cell cycle regulator, P27 possesses a verity of b iological functions, including regulation of cell cycle, induction of cell apoptosis, prom otion of celldifferentiation, etc. P27 gene is deleted, m utant or decreased in many solid tum ors, and its expression level is closely associated w ith the developm ent, progression, treatment, and prognosis of acute leukem ia. P27 can be used for targeted therapy of acute leukem ia by raising the level of P27 protein expression in leukem ia cells. P27 gene DNA methylation is only initially stud ied. P27 genemethylation in acute leukem ia and its rela tion w ith gene expression remains unclear, and whetherP27 genem ethylation can serve as an mi portant factor for early di agnosis and treatm ent of leukem ia still needs further discussion. [K ey words] P27 gene;