血管内皮生长因子及慢性阻塞性肺疾病继发肺动脉高压的关系.pdfVIP

·542· ．综述． 血管内皮生长因子与慢性阻塞性肺疾病 继发肺动脉高压的关系 吕倩 王昌明 【摘要】血管内皮生长因子(vascularendothelialfactor，VEGF)是一种重要的血管内皮细胞 growth 丝裂原和通透因子。肺血管的重塑与慢性阻塞性肺疾病(chronicobstructive disease，COPD) pulmonary 继发肺动脉高压密切相关。VEGF贯穿于COPD发展的全过程，在COPD的不同时期呈现不同的表达 水平，发挥不同的生物学作用。气道炎症、低氧等因素可以在COPD早期促进VEGF及其受体的表达上 调从而导致肺血管重塑的发生发展，VEGF也可以对COPD后期继发肺动脉高压时的重度肺血管重塑 起到一定的修复作用。通过阐述VEGF、COPD肺血管重塑及继发肺动脉高压之间的相互关系，可以对 COPD继发肺动脉高压的诊断和治疗提供新的思路。 【关键词】血管内皮生长因子；慢性阻塞性肺疾病；肺动脉高压；肺血管重塑 betweenvascularendothelialfactorand causedchronic Relationship growth pulmonaryhypertensionby obstructive diseaseLV Disease。the pulmonary Qian，WANGChang-ming．DepartmentofRespiratory CruilinMedical 541001，China A{{tliatedHospitalof College，Guilin author：WANG Corresponding Chang-ming，Email：ztlym@glmc．edu．讲 [Abstract]Vascularendothelialfactor(VEGF)isan endothelialcell and growth important mitogen vascular is relatedtothe permeabilityfactor．Pulmonaryremodelingclosely pulmonaryhypertension the causedchronicobstructivedisease(COPD)．VEGFentire ofCOPD by pulmonary gothrough process adifferentleveland adifferentroleofthe indifferentof development，whichexpress play biology stages can andotherfactors the ofVEGFandits COPD．Airwayinflammation，hypoxia promoteexpression inincreaseinthe vascular inthe of receptorsresulting incidenceofpulmonaryremodelingearlystage canalso acertainroleinthe ofsevere vascular inthe COPD．VEGFplay repairmentpulmonaryremodeling late ofCOPDwith