调控黑色素瘤转移的新信号蛋白 Syntenin.pdfVIP

中南大学学报(医学版) 2侃)7 ,32(2) 204 J c., SouJh U.脚(M.d 以) Syntenin : a novel PDZ domain-containing scaffolding protein associated with human melanoma metastasis Jian-bo Yang , James B. McCarthy (De，冉附nt tfμOOr.ω...， Me此. i，.. anJ Pallwlogy 由UJ Co呻reM1U闹 canar Cenur, Univmitr 01 Minn但榈， Minn.e叩曲， MN 55455 , USA) Abstract: Syntenin is overexpresseà in multiple human canωrs and is newly recognized 困 a novel regulator ín melanoma metastasis. It functions as a scaffolding proteín , via its two PDZ domains interacting with multiple transmembrane and cytoplasmic partners to reguJate many of the major signaling pathways involved in various cellu- lar P咀ce随e5 ， 5uch as cell surface receptor clustering , protein trafficking , cytoskeleton remodeling , and activation of transcription factor , and resulls in the increased abilities for tumor cell growth , adhesion , angiogenesis , invasion and metastasis. The pr回ent 国ticle altempts to review the structure and functions of syntenin by summarizing our current knowledge on the interacting partners and diverse signaling pathways related ωsyntenin ， and highlight 由e importance of synlenin 幽 a new potential lherapeutic target for the aggres5ive human melanoma. Key wor ds : syntenin; PDZ domain ; cell signaling ; melanoma metastasis [J Cent SQuth Univ (Med Sci) , 2007 ,32(2) :0204-09] 调控黑色素瘤转移的新信号蛋白: Syntenin Ji阳-bo Yang , James B. McCarthy (De阳rtmenl of Laboralory Medicine and Palhology and Comprehensive Cancer Cenl