MRI眶内结构定量测量在Graves眼病中的诊断价值：与CAS .docVIP

3T-MRI定量测量在Graves眼病诊断及分期中的价值 [摘要] 目的 探讨3T-MRI眶内结构定量测量在Graves眼病（Graves’ophthalmopathy, GO）中的诊断和分期23例Graves眼病患者与18例健康受试者行3.0T MRI扫描，分别测量眼球突出度、眼球内侧脂肪厚度、冠状位各眼外肌最大截面积以及眼外肌最高信号强度与同侧颞活动性clinical active score, CAS）进行相关分析，并采用ROC曲线法计算相关性最高的定量参数判断GO活动性P0.05）。眼外肌/颞肌信号强度比与CAS评分间相关性最高（r=0.730, P=0.000），以眼外肌/颞肌信号强度比≥ 3.25判断GO处于活动期的诊断效能最优（敏感度81.8%；特异度83.3%）。 3T-MRI眶内结构定量测量可辅助指导GO的临床诊断及分期。 [关键词] raves眼病测量；临床活动性评分 Diagnostic Value of 3T-MRI Quantitative Analysis of Orbital Structures in Graves’ Ophthalmopathy [Abstract] Objective To evaluate the diagnostic and staging value of quantitative measurement of orbital structures in patients with Graves’ophthalmopathy (GO) based on 3T-MRI . Methods Twenty-three GO patients (patient group) and eighteen healthy volunteers (control group) were enrolled for 3.0T MRI orbit scan. Quantitative measurement of orbital structures including exophthalmos values, fatty tissue thickness of the inner side of eye balls, cross-sectional areas of extraocular muscles and signal intensity ratios of extraocular muscles to the ipsilateral temporal muscles (SIR values) were compared between groups. Correlation between the quantitative values and clinical active score (CAS) were analyzed. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic value of using the most correlated quantitative value to discriminate active GO patients from the inactive ones. Results There were significant difference between the GO group and control group regarding to all the quantitative measurements (P0.05). Strong correlation was found between SIR values and CAS (r=0.730, P=0.000). The ROC curve showed that a SIR value of 3.25 might be the critical threshold value, with the diagnostic sensitivity of 81.8% and specificity of 83.3%, respectively. Conclusion 3T-MRI quantitative measurement of orbital structures could assist in diagnosing and staging GO. [Key Words] Graves’ophthalmopathy; MR imaging; Quantitative measurement; Clinical active s