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Progress in Retinal and Eye Research 31 (2012) 351e376 Contents lists available at SciVerse ScienceDirect Progress in Retinal and Eye Research journal homepage: /locate/prer Pax6: A multi-level regulator of ocular developmentq Ohad Shaham a, Yotam Menuchin a, Chen Farhy a, Ruth Ashery-Padan a,b, * a Sackler Faculty of Medicine, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel b Sagol School of Neuroscience, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel a r t i c l e i n f o a b s t r a c t Article history: Eye development has been a paradigm for the study of organogenesis, from the demonstration of lens Available online 3 May 2012 induction through epithelial tissue morphogenesis, to neuronal specification and differentiation. The transcription factor Pax6 has been shown to play a key role in each of these processes. Pax6 is required Keywords: for initiation of developmental pathways, patterning of epithelial tissues, activation of tissue-specific Pax6 genes and interaction with other regulatory pathways. Herein we examine the data accumulated over Lens the last few decades from extensive analyses of biochemical modules and genetic manipulation of the Retina