骨髓动员外周血干细胞移植治疗严重肢体缺血的临床应用.pdfVIP

浙江大学学报(医学版〉 Vo136 No 4 第 36 春第4 期 2007 年 ]OURNAL OF ZHE]IANG UNIVERSITY (MEDICAL SCIENCES) 2007 /med 骨髓动员外周血手细胞移植治疗 严重肢体缺血的临床应用 张鸿坤，李鸣，封竿，全埠，赵海格，陈龙东，回路 (茹江大学医学院酵属第一医镜血管外科，新江拉州 310003) [搞 要] 每盘古 z 探讨外离血千细胞移植改善严重缺血放体的作用。方锋 :15 倒下放严重缺血的患 者，经骨髓动员后，CS-3000Plus 机器采集外周血于细跑，直接移植入缺血成体中，共移植17 人次。 结果:采用骨牵主动员外琦血千细胞分离并移植治疗临床上严重肢体绞血的患者，术后一年，疼痛指 数由术前5. 。降到术后 0 ，琛舷指数(ABD 由术前0.30 提高到术后 0.46;6 钝渍荡5 倒愈合;无痛行 走距离由术前0.15 km 提高到术后0.72 km; 最大行走距离由求前0.96 km 提高到术后2.13 kmo 结 击告:骨髓动员外周血千细施移植能促进缺血是主体新生血管形成，有效改善缺血肢体的疼痛和步行距 离，并促进渍荡愈合。 [关键词] 千细月色;缺血;四肢/血液供给;干细胞移植;骨髓细胞 [中国分类号] R 338.13 [文献禄识码] A [文章编号] 1008-9292(2007)04-0360-04 Autologous transplantation of peripl主eral blood stem ceH in treatmen主 of critical limb ischemia ZHANG Hong-kun , LI Ming , FENG Hua , et al (Department 0/ Vascular Surgery. The First A//iliated H ospital ,College 0/ Medicine ,Zhejiang University ,H angzhou , 310003 ,China) [Abstract] Objectìve: To apply autologous transplantation of peripheral blood stem cells in the treatment of critical limb ischemia. Methods: Fifteen patients with critical lower limb ischemia wεre rεcruited in this study. After bone marrow mobilization ,pεriphe主al blood stem cells were collected using CS-3000 Plus device ,and transplanted directly into the ischemic limb. In total 17 times of transplantation were performed. Results: One year after implanted peripheral blood stem ceHs ,the pain scale decreasεd from 5 to 0 ,the ankle-brachial pressure index CABl) increasεd from O. 30 to O. 46 ,the pain-free walking distance and maximal walking distancεincreased from O. 15 to O. 72 km and O. 96 to 2. 13 km separately , from a total of 6 of 15 limb ulcers of transplanted patients 5 were healed after cεII transplantation.