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连续6年间鲍曼不动杆菌药物敏感率变迁及对策分析.pdf
上海交通大学学报(医学版)
.46.
Journal of Shanghai Jiaotong University (Medical Science) Vo l. 33 No.l Jan. 2013
[文章编号] 1674-8115(2013 )01-0046蛐 04 y 伦著·
连续6 年间鲍曼不动杆菌药物敏感率变迁及对策分析
肖淑珍E , 靡琛蓉z 韩立中1 , 陈旭1 , 倪语星I
(上海交通大学医学院附属瑞金医院1.临床微生物科, 2. 感染管理科,上海 200025)
[摘要] 国份了解鲍曼不动杆菌的临床分布及药物敏感率变迁,分析其耐药性发展趋势,为临床用药和感染控制提供依据并提出
相应对策。方旅收集2006 年 1 月 2011 年 12 月在该院临床微生物科分离得到并有药敏结果的鲍曼不动杆菌共2397 株,分析鲍
曼不动杆菌在各科室的分布情况。 K-B 法检测鲍曼不动杆菌对 13 种临床常用抗菌药物的敏感率。错J事连续6 年间临床分离的
鲍曼不动杆菌分布元明显变化,主要分布于烧伤科、心胸外科、普外科、呼吸科、血液科和老年科等科室;对常用抗菌药物的敏感率
呈整体下降趋势。门诊及内科分离的菌株对三代头抱、噎诺嗣类和氨基糖背类的敏感率相对较高,而急诊、外科和重症监护病房
(ICU) 分离的菌株敏感率相对较低。错俗鲍曼不动杆菌对抗菌药物的敏感率逐年降低,需引起临床的高度重视。不同科室分离的细
菌耐药谱不一致,临床民师需根据细菌的药物敏感性试验结果合理选用抗菌药物;同时还应加强医院感染监控,减少耐药菌的传播。
[关键词]鲍曼不动杆菌;耐药;感染;抗菌药物
[DOI] 10. 3969/j. issn. 1674-8115.2013.01. 009 [中国分类号] R446.5 [文献标志码] A
Variation of drug susceptibility of Acinetobacter baumannii within 6 years and
countermeasure analysis
2
XIAO Shu-zhen , MI Chen-rong , HAN Li-zhong , CHEN Xu , NI Yu-xing
(1. Department of Clinical Microbiology , 2. Infection Control Depαrtment, Ruijin Hospital , Shanghai Jiaotong University
School of Medicine , Shanghai 200025, China)
[Abstract] Objective To investigate the clinical distrihution and variation of drug resistance of Acinetobacter baum日nnlL,
and provide reference for antibiotic drug usage and infection contro l. Methods A total of 2 397 clinical isolates of
Acinetobαcter bαumannii with result of drug sensitivity test were collected from Department of Clinical Microbiology of the
hospital , and the distribution of isolates of Acinetobacter baumannii in clinical departments was analyzed. The sensitivity of
Acinetobacter baumannii to 13 commonly used antibiotic drugs was determined by K-B method. Results There was no
significant ch
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