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• 293 • 国外医学卫生学分册 2007 年 第 34 卷第5 期 in asbesωs t.reated immortalized human hronchial epithelial marker of biolo原cal immortality of genn , stem. and canωr cells [J]. Oncogene , 2∞2 ， 21(49): 7471翩7477. cells [JJ. Biochemis盯 (MOI町)， 1叨，但(11): 1323- 1331. [20] MAYEUR G L , HERSHEY J W. Malignant transfonnation [26J SHAY J W , GAZDAR A F. Telomerase in the early hy the eukaryotic translation initiation factor 3 suhunit p48 detection of cancer[JJ . J Clin Pathol , 1997 , 50(2): 106- (eIF3 e) [JJ. FEBS Le忧， 2∞2 ， 514( 1) :49-54. 109. [21 J CHEN R 日， M阻γTINEN P 1, MANUOKA E M , et al. A [27J 王敏，目嘉春.结晶型硫化镰诱发细胞，恶变过程中 WD-domaìn proteìn that ìs as舶ciated with and 端锚聚合酶 mRNA 的表达 [JJ. 癌变·畸变·突变， phosphorylated by the type II TDF-.beta receptor [J J . 2创6， 18(4): 314-315. Nature , 1995 , 337 (6549): 548-552. [28] YE J , SHI X. Gene expression profile ìn response to [22J JOS院PH P , LEI Y X , WHONG W Z , et al. Molecular chromium-induced cell stress in A549 cells [J]. Mol Cell clonìng and functional analysis of a novel cadmium唰 Bioch棚， 2∞1 ， 222(1 -2): 18弘197. responsive proto-oncogene [J J. Cancer Res , 2∞2 ， 62 [29J ZHAO Y L , PIAO C Q, WU L J, et a 1. Diferentially (3): 703-707. expressed genes in asbestos-ìnduced tumorigenic human [23J 魏蔬，雷毅雄，王敏，等. 16日BE 细胞恶性转化过程 bronchial epithehal cells: implication for mechanism [J J . 中 TIF3 p36 的变化 [J] .中华劳动卫生职业病杂志， Carcinogen , 2000 , 21 ( 11): 2∞5-2010. 2ω6， 24(10) :578恤581. [30J MIURA K , BOWMAN 区 D， SIMON R , et a 1. Laser [24] LEI Y X, CHEN X M , WU G R , et al. Ahnorm