药动学-药效学结合模型的研究进展和应用.PDFVIP

·综 述 · 药动学-药效学结合模型的研究进展及应用 孙敏捷，许颖( 中国药科大学药学院，南京 210009) 摘要：目的 综述药动学-药效学(PK-PD)结合模型的研究进展。方法 对近十年来国内外发表的具有代表性的相关文章 进行分析、整理和归纳，总结 PK-PD 结合模型的类型、程序及应用。结果 PK-PD 结合模型有 4 种类型，其在新药研发， 个体化给药和临床检测等方面都有广泛的应用，为临床用药提供了有力的指导。结论 PK-PD 模型随着研究的深入不断 完善，在药物开发和研究中发挥了重要的作用。 关键词：药动学；药效学；药动学-药效学结合模型；常用程序；研究进展 中图分类号：R965 文献标志码：A 文章编号：1007-7693(2010)11-1084-06 Recent Advances and Application of Pharmacokinetic-pharmacodynamic (PK-PD) Modeling SUN Minjie, XU Ying(School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China) ABSTRACT: OBJECTIVE To review the advances on pharmacokinetic-pharmacodynamic (PK-PD) modeling. METHODS On the basis of analysing and concluding the relevant articles for the last ten years, the types, programs and application of PK-PD modeling were summarized. RESULTS There are four kinds of pharmacokinetic-pharmacodynamic (PK-PD) modeling, which were widely applied on drug development, individual administration and clinical detection, providing useful information to guide clinical medication. CONCLUSION PK-PD modeling has been improved and plays important role in drug development with its deep study. KEY WORDS: pharmacokinetic; pharmacodynamic; pharmacokinetic-pharmacodynamic (PK-PD) modeling; common programs; rencent advances 药动学，即药动学(pharmacokinetics ，PK)和 应随时间变化的规律。近些年来，PK-PD 模型在 药效动力学，即药效学(pharmacodynamics ，PD) 新药研发，个体化给药，临床药物检测(TDM) 中有 是临床药理学的 2 个重要的组成部分，药动学， 了广泛的应用[1] [2] ，尤其是在指导抗菌药物 ，抗结 指用动力学(kinetics) 的原理与数学模式，定量描述 核药物[3] [4] ，心血管系统药物 ，作用于神经系统药 药物进入体内的吸收、分布、代谢和排泄过程中 物[5]等药物的临床合理用药及优化给药方案上研 血药浓度随时间动态变化的规律，阐明机体对药 究较多。对 PK-PD