干细胞在肾脏再生中应用研究进展.PDFVIP

·2398 · 中华临床医师杂志( 电子版)2015 年6 月第9 卷第12 期 Chin J Clinicians(Electronic Edition),June 15,2015,Vol.9,No.12 ·综述· 干细胞在肾脏再生中的应用研究进展 耿晓东 1,4 耿俊 2 张航 3 崔杰 3 吴镝 4 【摘要】 终末期肾病加剧了世界医疗资源的负担。现在迫切需要有效的策略，通过肾脏再生 来预防进一步的肾损伤以及恢复肾功能。除了防止肾脏损伤，再生受损的肾组织对于延缓慢性肾脏 疾病发展到终末期肾衰竭也是非常重要的。几种类型的干细胞，包括骨髓来源的细胞，脂肪来源的 间充质干细胞，胚胎干细胞和诱导多能干细胞都可应用于肾脏再生。基于这些研究和知识，我们希 望能够创新更可靠的生物工程方法来应用于肾脏再生领域。 【关键词】 干细胞； 生物工程肾； 肾脏再生 , 1 4 2 3 Research progress of stem cells in kidney regeneration Geng Xiaodong , Geng Jun , Zhang Hang , Cui Jie3 4 1 3 , Wu Di . Department of Nephrology, Department of Medical Affairs, Beidaihe Sanatorium of Beijing Military Region, Qinhuangdao 066100, China; 2Psychological Counseling Center, Capital Normal University, Beijing 100048, China; 4Department of Nephrology, Chinese PLA General Hospital, Beijing 100853, China Corresponding author: Wu Di, Email: wudi@301 【Abstract 】 Kidney disease is an escalating burden all over the world. In addition to preventing kidney injury, regenerating damaged renal tissue is as important as to retard the progression of chronic kidney disease to end stage renal disease. Several types of stem cells, such as bone marrow-derived cells, adipocyte-derived mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells are also applied for renal regeneration. Based on these studies and knowledge, we hope to innovate more reliable biotechnical methods for kidney regeneration medicine. 【Key words 】 Stem cells; Bioengineered kidney; Kidney regeneration 广义上讲，肾脏再生包括肾脏修复和部分或全 有针对性地促进损伤肾脏细胞的修复再生。 部肾单位再生。肾发育，即再生肾单位的每一