雷公藤与其安全性_孙新.pdfVIP

Chinese Journal of New Drugs 2001, Vol. 10 No. 7 2001 10 7 , , , , , ( 国家药品监督管理局药品评价中心 国家药品不良反应监测中心, 北京100061) [] 雷公藤具有显著的免疫调 作用, 临床上用于治疗风湿性关 炎系统性红斑狼疮肾脏疾病等, 其 临床不良反应的发生率也远高于其他药物, 主要发生在消化系统泌尿系统生殖系统心血管系统骨髓及血液系 统开发雷公藤新剂型, 减低其毒性, 对满足临床用药具有重大的意义 [] 雷公藤; 安全性; 药物不良反应 [ ] R971. 1 [ ] B [ ] 1003- 3734(2001) 07- 0539- 05 Safety of Trip terygium Wilf ordii SUN Xin, ZHANG Su-min, IAN Chun-hua, YANG Lin, WANG Lan-ming, LI Shao-li ( N ational Cent er f or A D Rs M oni tor ing , Cent er f or D rug Reev al uation, SDA , Beij ing 100061, Chi na) [ Abstract] Tr ip teryg ium Wifl ord i i , a traditional Chinese herb, was reported to have im- munoregulatory effects. It has been used in clinic for treatment of rheumatoid arthritis, systemic lupus erythematosus and kidney disease. But it is toxic, with an incidence of ADRs significantly higher than other drugs. he organal systems affected by ADRs of T rip teryg ium Wifl ord i i were gastrointestinal, urogenital, cardiovascular, blood circulatory systems as well as bone marrow . herefore, development of new preparations to reduce its toxicity is in need to satisfy clinical uses. [ Key words] t rip teryg ium w ilf or d ii ; safety; adverse drug reactions ( T rip teryg ium w ilf or d ii Hook. f. ) 1. 2 , 1.2 . 1 ( triptolide) ( tripdiolide) ( tripterolide) ( T H yp og laucum ( Levl. ) H ukeda .) , (triptonide) ( triptolidenol) ( T For reti i D ials ) 1.2 .2 ( hypoline) [ 1] ( T Regell i Sp r ag ue et Takeda ) ( triptorolide) (neotripto-