右丙亚胺在老年乳腺癌辅助化疗中对心脏的保护作用.pdf

现代肿瘤医学 2016年 08月 第 24卷第 15期 MODERNONCOLOGY，Aug．2016，VOL24，NO．15 ·2391· 右丙亚胺在老年乳腺癌辅助化疗中对心脏的保护作用 王炳高 ，袁新颜 ，王 丽 ，侯 红 ，邢志博 ，李振凤 Protectiveeffectofdexrazoxaneontheheartinelderlybreastcancerpatientsafteradju- vantchemotherapy WangBinggao ，YuanXinyan ，W angLi，HouHong ，XingZhibo ，LiZhenfeng DepartmentofBreastSurgery，SecondAffiliatedHospitalofQingdaoUniversityMedicalCollege，ShandongQingdao266042， China；DepartmentofGynecologyandObstetrics，QingdaoSpinal—DiseaseHospital，Shan ngQingdao266041，China． 【Abstract】 Objective：Toexploretheprotectiveeffectofdexrazoxane(DZR)ontheheartforpostoperativeelderly breastcancerpatientswithpirarubicin(THP)adjuvantchemotherapy．Methods：All120elderlybreastcancerpa— tientstreatedwithCTFchemotherapyregimens(CTX+THP+5一FU)inourhospitalwererandomlyassignedinto observationgroupandcontrolgroup：Thecontrolgroup(withoutDZR)andobservationrgoup(withDZR)(DZR： THP=10：1)．Cardiacfunctionalstatusandnon—cardiactoxicitywereobservedbeforetreatment，thefirstcycleof treatment，thethirdcycle，thesixthcycleoftreatment，sixmonthsafterthecompletionandoneyearafterthecomple— tion，withmonitoringthecardiactroponinT(cTnT)，B—typenatriureticpeptide(BNP)andleftventricularejection fraction(LVEF)．Results：Intworgoupstherewerenostatisticaldifferences(P0．05)inage，weight，ECOGscore andstaging．ThecTnT，BNPvalueofpatientsincontrolincreasedobviouslyinthefirstcycle，andreachedthemaxi- mum attheendofthetreatmentandmaintainedatahigherleveluntiloneyearaftertreatment．ThevalueofcTnTwas low inobservationgroupduringtreatmentandaftertreatment，whiletheLVEF levelbetweenthetwogroupshadno statisticaldifferencesinallstagesoftreatment(P0．05)．Therewasnodifferenceinnon—cardiacsideeffectsbe— tweenthetwogroups．Conclusion：TheapplicationofTHPhasobvioustoxicityontheheart．DZR canreducethecar— diactoxicity． K【eywords】elderlybreastcancer，adjuvantchemo