Isocitrate_Dehydrogenase_(IDH)抑制剂_激动剂_MCE.pdf

Isocitrate Dehydrogenase (IDH)   Isocitrate dehydrogenase (IDH) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producingalpha-ketoglutarate (alpha;-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate(a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as themitochondrion and peroxisome. www.MedChemE 1 Isocitrate Dehydrogenase (IDH) Inhibitors Modulators (R,S)-Ivosidenib AGI-5198 ((R,S)-AG-120; (R,S)-AG 120; (R,S)-AG120) Cat. No.: HY-18767A (IDH-C35; AGI5198; AGI 5198; IDH C35) Cat. No.: HY-18082 Bioactivity: