乳酸杆菌S-层蛋白的特性与功能性研究进展.PDF

微生物学通报 May 20, 2017, 44(5): 1206−1213 Microbiology China /wswxtbcn tongbao@ DOI: 10.13344/j.microbiol.china.160456 专论与综述 乳酸杆菌S-层蛋白的特性及功能性研究进展 * 石晓璐 张英春 张兰威 向鑫玲 ( 150090) 摘 要：文章综述了S-层蛋白的性质和功能，重点介绍了S-层蛋白对乳酸杆菌表面性质和黏附性 的影响以及调节肠道功能的作用，包括减少病原菌引起的细胞凋亡、调节免疫细胞的活性、与 SIGNR3 相互作用参与肠道免疫反应、通过TLRS-MyD88-NF-κB 途径发挥生物学功能以及调控肠 道黏膜相关蛋白表达。由此证明了S-层蛋白对于乳酸杆菌发挥免疫调节功能具有重要的作用。 关键词：S-层蛋白，乳酸杆菌，肠道，免疫调节 Research progress on the features and functions of Lactobacillus S-layer protein * SHI Xiao-Lu ZHANG Ying-Chun ZHANG Lan-Wei XIANG Xin-Ling (Department of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150090, China) Abstract: In this paper, the properties and functions of Lactobacillus S-layer protein were reviewed. The effects of S-layer protein on surface-properties, adhesion capacities of Lactobacillus bacteria and the regulation of intestinal function are also introduced, including reducing apoptosis caused by pathogenic bacteria, immunoregulating cell activity, participating in the intestinal immune response through the interaction with SIGNR3, exerting biological function through TLRS-MyD88-NF-κB pathway and regulating expression of intestinal mucosa associated proteins. Thus demonstrated that S-layer protein plays an important role in the function of immunoregulatory effect. Keywords: S-layer protein, Lactobacillus , Gut, Immunoregulatory S-(Surface layer pro