国产海藻酸钠载药微球在原发性肝癌TACE治疗中安全性探析.docVIP

国产海藻酸钠载药微球在原发性肝癌TACE治疗中安全性探析 　　【摘要】 目的 探?国产海藻酸钠载药微球在原发性肝癌肝动脉插管化疗栓塞术（TACE）治疗中的安全性。方法 60例原发性肝癌患者， 随机分为海藻酸钠组和碘化油组， 每组30例。海藻酸钠组接受国产海藻酸钠载药微球进行动脉化疗栓塞， 碘化油组采用碘化油进行动脉化疗栓塞， 评价血常规、肝功能以及并发症情况。结果 TACE术后， 两组患者白细胞、红细胞和血小板降低情况比较差异无统计学意义（P0.05）。两组患者总胆红素（TBIL）增高、间接胆红素（IBIL）增高、谷丙转氨酶（ALT）增高、谷草转氨酶（AST）增高和白蛋白（ALB）降低情况比较差异无统计学意义（P0.05）。海藻酸钠组患者并发腹痛16.7%（5/30）低于碘化油组的60.0%（18/30）， 差异有统计学意义（P0.05）。结论 国产海藻酸钠载药微球在原发性肝癌TACE治疗中是安全的， 可在临床使用 【关键词】 肝动脉插管化疗栓塞术；原发性肝癌；海藻酸钠；碘化油；安全性 DOI：10.14163/j.cnki.11-5547/r.2017.01.014 Analysis on security of domestic sodium alginate microsphere for drug carrier in primary hepatic carcinoma by TACE treatment LIU Mo， HUANG Wu-kui， LIU Deng-yao， et al. Department of Interventional Diagnosis and Treatment （Intervention Room）， Xinjiang Uygur Autonomous Region Xinjiang Medical University Affiliated Tumor Hospital， Urumchi 830011， China 【Abstract】 Objective To explore security of domestic sodium alginate microsphere for drug carrier in primary hepatic carcinoma by transcatheter arterial chemoembolization （TACE） treatment. Methods A total of 60 primary hepatic carcinoma patients were randomly divided into sodium alginate group and iodinated oil group， with 30 cases in each group. The sodium alginate group received domestic sodium alginate microsphere for drug carrier for transcatheter arterial chemoembolization， and the iodinated oil group received iodinated oil for transcatheter arterial chemoembolization. Evaluation were made on routine blood， liver function and complications. Results After TACE oparation， both groups had lower white blood cells， red blood cells and platelets than before operation， but there were no statistically significant difference in two groups （P0.05）. Both groups had higher total bilirubin （TBIL）， indirect bilirubin （IBIL）， alanine transaminase （ALT） and aspartate aminotransferase （AST）， and lower albumin （ALB） than before operation， but there were no statistically significant difference in two groups （P0.05）. The sodium alginate group