DNA水平自然选择作用的检测_周琦.pdfVIP

　　　　　2004, Feb.25 (1):73～ 80 CN 53-1040/Q　ISSN 0254-5853 Zoological Research DNA 周　琦, 王　文＊ (, , 　650223) 　　 60 , Kimura “” : 。 :DNA , “” 。 DNA , 。 DNA :。 Tajima (1989)D , “, ” 。 , DNA , “”。 。, 。 　　 ;DNA; : :Q31;Q 111 　:A 　:0254-5853(2004)01-0073-08 Detecting Nat ral Selection at the DNA Level Z HOU Qi, WA NG Wen ＊ (CAS-Max Planck Junior Scientist Group , K ey Laboratory of Cellular and Molecular Evolution, Kunmin Institute of Zoolo y , the ChineseAcademy of Sciences, Kunmin 　650223, China) 　　Abstract:In the 1960s, the neutral theory ro osed by Kimura caused an un recedented challenge to the classical Darwin s theory of natural selection.However, recent advances in evolutionary genetics have rovided a great deal of evi- dence on the role layed by natural selection at the DNA level.These rogresses have been stemmed from the a earance of enormous DNA sequence data of o ulations and genomes as well as the develo ment of theoretical o ulation genetics. There are mainly two kinds of a roaches to detect selection at the DNA level:intras ecific olymor hism tests and inter- s ecific divergence tests.The former one is re resented by Tajima s (1989)D test while the latter one is based on the rinci le that the intras ecific olymor hism should be consistent with the inters ecific divergence under neutrality.These methods are usually called “neutrality tests” because the neutrality hy othesis is taken as the null hy othesis in the tests. They are im ortant tools not only in solving the basic theoretical questions in evolutionary biology but also in inter reting data and results obtained in the studies of human genetics and bioinformatics.In this a er