002细胞膜及其表面1.ppt

第二篇 细胞膜及其表面;第二篇 细胞膜及其表面;;;;;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;磷酸胆碱; ; ;鞘磷脂;;胆固醇;胆固醇分子结构(A)及其在细胞膜中的位置(B);;;;葡萄脑苷脂;Glycolipids;脂在水中的行为;(a)水溶液中的磷脂分子团；(b)球形脂质体； (c)平面单层脂质体膜；(d)用于疾病治疗的脂质体的示意图 ;;;;;;;; 1).糖磷脂酰肌醇(GPI)连接的蛋白： 用磷脂酶C(能识别含肌醇的磷脂)处理细胞，能释放出结合的蛋白。许多细胞表面的受体、酶、细胞粘附分子和引起羊瘙痒病的PrPC都是这类蛋白。 2).另一类脂锚定蛋白与插入质膜内小叶的长碳氢链结合。 ;;;整合蛋白;跨膜多肽链以α螺旋的方式穿过脂质双层;外周蛋白;脂锚定蛋白;末端氨基酸与脂肪酸之间的酰胺键;①,② integral protein；③,④ lipid-anchored protein ⑤,⑥ peripheral protein；;A typical single-pass trans-membrane protein. Note that the polypeptide chain tra-verses the lipid bilayer as a right-handed a helix and that the oligosaccharide chains and disulfide bonds are all on the noncytosolic surface of the membrane. Disulfide bonds do not form between the sulfhydryl groups in the cytoplasmic domain of the protein because the reducing environment in the cytosol maintains these groups in their reduced(-SH)form.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;The three-dimensional structure of a bacteria rhodopsin molecule. The polypeptide chain crosses the lipid bilayer as seven a helices.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;糖与多肽连接的两种方式;MN血型糖蛋白在红细胞膜中的结构方式 (多肽链含有131个氨基酸残基。在脂质双层中约有30个氨基酸残基以α—螺旋通过);半乳糖;;;细胞膜的研究历史;;;;;Polar ;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;在Langmuir水盘中展现脂单层; c).Lipid bilayer ;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Danielli-Davson片层膜结构模型(修改