缺血再灌注损伤的发病机制.pptVIP

Sporulation yeast pheromone scaffold adenosine is an endogenous cardioprotectant released during ischemia that exerts its beneficial effects via opening of mitochondrial KATP channels through interaction with the A1 and A3 receptors on cardiomyocytes. Despite marked beneficial effects of adenosine therapy in experimental models of ischemia and reperfusion, the clinical experience has been limited. 再灌注性心律失常（Reperfusion Arrhythmias） Reperfusion时，通过Na+-Ca2+交换形成一过性内向离子流，在心肌动作电位后形成短暂除极，持续Ca2+内流，可形成动作电位的“第二平台期”而引发早期后除极或延迟后除极，导致reperfusion arrhythmias。 再灌注性心律失常（Reperfusion Arrhythmias） 在心肌缺血-再灌注过程